Characteristics of acute transverse myelitis at Aga Khan University Hospital, Karachi.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Journal of the Pakistan Medical Association Pub Date : 2007-04-01

Arslan Akbar Kahloon, Hiba Arif, Shahid Masud Baig, Muhammad Rizwanulhaq Khawaja

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Abstract

Objective: To determine the presenting features and etiological classification of acute transverse myelitis (ATM) at Aga Khan University Hospital, a tertiary care hospital in Pakistan.

Methods: Twenty consecutive patients of ATM (1996-2003) fulfilling a preset criterion were analyzed for demographic features, clinical presentation, laboratory investigations and neuro-imaging.

Results: Half of the patients were males and their median age was 29 years (range 6-73 years). Fever, paraparesis, quadri-paresis and bladder dysfunction were the most common presentations. Median score on disability rating scale (DRS) was twelve. Sixty percent of the patients were classified as Idiopathic-ATM while 30% and 10% as Para infectious associated-ATM and Multiple sclerosis associated-ATM respectively.

Conclusion: Idiopathic acute transverse myelitis is the most common type of ATM in the studied population. Our data suggested that the severity of motor impairment is greater in our population than that reported in western literature which might hint to different genetic or environmental etiological factors involved in the pathogenesis of acute transverse myelitis.

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卡拉奇阿迦汗大学医院急性横断面脊髓炎的特点。

目的:了解巴基斯坦三级医院阿迦汗大学医院急性横断面脊髓炎(ATM)的临床表现及病因分型。方法:对1996 ~ 2003年连续20例符合标准的ATM患者的人口学特征、临床表现、实验室检查和神经影像学检查进行分析。结果:半数患者为男性，中位年龄29岁(6 ~ 73岁)。发烧、麻痹、四肢麻痹和膀胱功能障碍是最常见的表现。残疾评定量表(DRS)中位数为12分。特发性atm占60%，伴感染性atm占30%，多发性硬化症atm占10%。结论:特发性急性横贯脊髓炎是研究人群中最常见的ATM类型。我们的数据表明，我国人群中运动障碍的严重程度比西方文献报道的要大，这可能暗示了不同的遗传或环境病因参与了急性横贯脊髓炎的发病机制。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.