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Beyond Dialysis: Reshaping CKD Paradigms in Developing Nations. 超越透析:发展中国家重塑慢性肾功能衰竭范例。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.11541
Muhammad Tayyab Ijaz, Namra Ijaz
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引用次数: 0
Effects of Kabat rehabilitation versus mime therapy on facial disability and synkinesis in patients of Bell's palsy. 卡巴特康复疗法与哑剧疗法对贝尔麻痹患者面部残疾和同步运动的影响。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.11247
Ayesha Amjad, Ayesha Jamil, Nida Fatima, Hira Bano Javaid, Hafsa Zahid

Objective: To compare the effects of Kabat rehabilitation and Mime therapy on facial disability and synkinesis in patients with Bell's palsy.

Methods: The single-blind, randomised clinical trial was conducted at the Physiotherapy Department of the University of Lahore Teaching Hospital, Lahore, Pakistan, from May to October 2023, and comprised adults of either gender aged 25-50 years having sub-acute or chronic unilateral Bell's palsy of non-congenital origin. The patients were randomised into Kabat rehabilitation group A and mime therapy group B. Conventional physical therapy was given to both groups additionally. Facial disability was assessed using the Facial Disability Index scale, and synkinesis was observed using the House-Brackmann Facial Nerve Grading Scale. Data was analysed using SPSS 25.

Results: Of the 72 patients, 41(56.9%) were females and 31(43.1%) were males. The overall mean age was 37.77±6.98 years, mean body mass index was 25.71±5.71kg/m2 and 41(56.9%) patients had left-sided palsy. Facial disability and synkinesis were significantly different in both groups post-intervention (p<0.001), while intergroup differences were significant in the 3rd and 6th weeks (p<0.001).

Conclusions: Kabat rehabilitation led to more significant improvements in synkinesis and facial disability compared to mime therapy.

Clinical trial number: Clinical trials.gov registration id: NCT06029855.

目的:比较卡巴特康复疗法和默剧疗法对贝尔麻痹患者面部残疾和同步运动的影响:比较卡巴特康复疗法和默剧疗法对贝尔麻痹患者面部残疾和同步运动的影响:该单盲随机临床试验于 2023 年 5 月至 10 月在巴基斯坦拉合尔的拉合尔大学教学医院理疗科进行,对象为 25-50 岁患有亚急性或慢性单侧非先天性贝尔氏麻痹的成年男女患者。患者被随机分为卡巴特康复治疗 A 组和默剧治疗 B 组。面部残疾采用面部残疾指数量表进行评估,同步运动采用 House-Brackmann 面部神经分级量表进行观察。数据使用 SPSS 25 进行分析:72 名患者中,女性 41 人(56.9%),男性 31 人(43.1%)。总平均年龄为(37.77±6.98)岁,平均体重指数为(25.71±5.71)kg/m2,41 例(56.9%)患者为左侧瘫痪。干预后,两组患者的面部残疾和同步运动均有显著差异(P结论:与哑剧疗法相比,卡巴特康复疗法对同步运动和面部残疾的改善更为显著:临床试验编号:Clinical trials.gov registration id:临床试验编号:Clinical trials.gov registration id:NCT06029855。
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引用次数: 0
The effectiveness of liver function tests in the prediction of mortality in patients with COVID-19. 肝功能检测在预测 COVID-19 患者死亡率方面的有效性。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.10832
Erdi Huseyin Erdem, Bahar Aydinli, Serkan Dogru, Harun Ozmen

Objectives: To evaluate the impact of liver function test abnormalities on mortality in critically ill coronavirus disease- 2019 patients.

Methods: The single-centre, retrospective study was conducted at the Department of Anaesthesiology and Reanimation, Mersin City Training and Research Hospital, Turkiye, and comprised data from March 2020 to January 2022 of patients with positive real-time reverse transcription polymerase chain reaction test on nasopharyngeal swab sample for coronavirus disease-2019. Comorbidities, demographic data, admission to and discharge from the intensive care unit, Acute Physiology and Chronic Health Evaluation II scores, complete blood count on the first and second day of hospitalisation, coagulation parameters, biochemical analysis, 7-day, 28-day and total mortality of the patients in the intensive care unit were recorded. The patients were then divided into groups, with Group 1 having patients with normal liver enzymes, Group 2 having patients with abnormal liver enzymes, and Group 3 having patients with liver damage. Data was analysed using SPSS 20.

Results: Of the 940 subjects, 587(62.4) were males and 353(37.6) were females. The overall mean age of the patients was 67.11±16.65 years. There were 395(42%) patients in Group 1, 534(56.8%) in Group 2 and 11(1.2%) in Group 3. Gamma-glutamyl transferase-1s, aspartate aminotransferase-2nd and albumin-2nd were significant predictors of mortality (p<0.05).

Conclusion: High gamma-glutamyl transferase, aspartate aminotransferase and low albumin levels in critically ill coronavirus disease-2019 patients could be considered indicators of high mortality rate.

目的:评估肝功能检测异常对2019年冠状病毒病重症患者死亡率的影响:评估肝功能检测异常对2019年冠状病毒病重症患者死亡率的影响:该单中心回顾性研究在土耳其梅尔辛市培训与研究医院麻醉与复苏科进行,研究对象为鼻咽拭子样本实时反转录聚合酶链反应检测结果呈阳性的冠状病毒病-2019患者,研究时间为2020年3月至2022年1月。研究记录了重症监护室患者的合并症、人口统计学数据、入院和出院情况、急性生理学和慢性健康评估 II 评分、住院第一天和第二天的全血细胞计数、凝血参数、生化分析、7 天、28 天和总死亡率。然后将患者分为三组,第一组为肝酶正常患者,第二组为肝酶异常患者,第三组为肝损伤患者。数据使用 SPSS 20 进行分析:在 940 名受试者中,男性 587 人(62.4%),女性 353 人(37.6%)。患者的平均年龄为(67.11±16.65)岁。第一组有 395 人(42%),第二组有 534 人(56.8%),第三组有 11 人(1.2%)。γ-谷氨酰转移酶-1s、天门冬氨酸氨基转移酶-2nd和白蛋白-2nd是预测死亡率的重要指标(p结论:2019年冠状病毒病重症患者的γ-谷氨酰转移酶、天门冬氨酸氨基转移酶和白蛋白水平较高,可视为高死亡率的指标。
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引用次数: 0
Histopathological pattern in endometrial biopsies in reproductive age group and Post-menopausal women. 育龄期和绝经后妇女子宫内膜活检组织病理学模式。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.11352
Farah Fatima Abbas, Uzma Bukhari, Nehad Khan, Fatima Arshad, Saba Kamil

Objectives: To identify and analyse the different types and frequencies of morphological pattern in endometrial biopsies along with their associated diagnoses across different age groups.

Methods: The cross-sectional study was conducted at the Histopathology Section of the Dow Diagnostics Reference and Research Laboratory, Dow University Health Sciences, Karachi, from October 2022 to October 2023. Data was obtained from pre-existing medical record of samples of endometrial biopsies. Open Epi sample size calculator is used for the estimation of sample size. The patients were divided into two aged-based groups; reproductive age ≤45 years in group 1 and postmenopause age ≥46 years in group 2. The histological diagnosis was made by a consultant histopathologist.

Results: Of the 430 endometrial biopsies 222(51.6%) were in group 1 and 208(48.4%) were in group 2. In both groups, the most common finding was polyps 271(63%). Malignant changes were found in 12(5.7%) group 2 cases compared to 4(1.8%) group 1 cases.

Conclusions: The most common endometrial lesion in both age groups was endometrial polyp. Malignant changes were seen more in postmenopausal women compared to those in the reproductive age group.

目的确定并分析不同年龄组子宫内膜活组织检查中形态模式的不同类型和频率,以及与之相关的诊断:这项横断面研究于 2022 年 10 月至 2023 年 10 月在卡拉奇陶氏大学健康科学学院陶氏诊断参考与研究实验室组织病理学组进行。数据来自子宫内膜活检样本的已有医疗记录。样本量的估算使用 Open Epi 样本量计算器。患者按年龄分为两组:生育年龄≤45岁为第一组,绝经后年龄≥46岁为第二组,组织学诊断由组织病理学顾问做出:结果:在 430 例子宫内膜活检中,第 1 组有 222 例(51.6%),第 2 组有 208 例(48.4%)。第二组有 12 例(5.7%)发现恶性病变,而第一组只有 4 例(1.8%):两个年龄组最常见的子宫内膜病变都是子宫内膜息肉。与育龄期妇女相比,恶性病变更多见于绝经后妇女。
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引用次数: 0
Inspecting the potential of thymol as a therapeutic agent for treating Alzheimer's disease. 研究百里酚作为治疗剂治疗阿尔茨海默病的潜力。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.10718
Muhammad Waleed Imran, Sanwal Sardar Nawaz, Muhammad Moaz
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引用次数: 0
Dysregulated renal tubular handling of filtered glucose in patients with type 2 diabetes mellitus: A descriptive study. 2 型糖尿病患者肾小管对过滤葡萄糖的处理失调:一项描述性研究
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.11415
Asim Zulfiqar, Saira Jahan, Muhammad Nadim Akbar Khan, Shamaila Burney, Muhammad Farooq, Kiran Fatima

Objective: To determine the frequency of suspected dysregulated renal tubular handling of filtered glucose, and its association with blood glucose levels in type 2 diabetes mellitus.

Methods: The analytical, cross-sectional study was conducted from November 2022 to June 2023 at the Department of Medicine along with the Department of Pathology and Biochemistry, Pakistan Railway Hospital, Islamic International Medical College, Rawalpindi, Pakistan, and comprised diabetics aged 19-80 years. Blood and urinary glucose were assessed at the point of contact. Blood glucose 80-180mg/dl was considered glucose in range and >180mg/dl glucose above range. Hyperfunction of sodium glucose transport receptors was suspected if urinary glucose was <++ and the function of these receptors was considered normal if urinary sugar was ++ or more. Association of suspected receptors functioning and their association with blood glucose levels was determined. Data was analysed using SPSS 26.

Results: Of the 159 diabetics, 91(57%) were females and 68(43%) were males. The overall mean age was 57±11 years (range: 46-68 years). Of the total, 43(27%) patients had glucose in range and 116(73%) had glucose above range. Of the diabetics with glucose above range, 54(47%) patients had hyper-functioning sodium glucose transport receptors, and 62(53%) had normal functioning sodium glucose transport receptors. Of the patients with glucose in range, 11(26%) had hyperfunctioning sodium glucose transport receptors, and 32(74%) had normal functioning sodium glucose transport receptors. There was a significant association between sodium glucose transport receptors' function and blood glucose levels (p<0.001).

Conclusion: Dysfunction of sodium glucose transport receptors affected the secretion of glucose in the urine, resulting in impaired glucose regulation in type 2 diabetes mellitus cases.

目的确定疑似2型糖尿病患者肾小管处理滤过葡萄糖功能失调的频率及其与血糖水平的关系:这项分析性横断面研究于 2022 年 11 月至 2023 年 6 月在巴基斯坦拉瓦尔品第伊斯兰国际医学院巴基斯坦铁路医院医学系和病理学与生物化学系进行,研究对象包括 19-80 岁的糖尿病患者。在接触点对血糖和尿糖进行评估。血糖 80-180 毫克/分升被认为是在血糖范围内,而大于 180 毫克/分升的血糖则超过了血糖范围。如果尿糖结果正常,则怀疑葡萄糖钠转运受体功能亢进:在 159 名糖尿病患者中,91 名(57%)为女性,68 名(43%)为男性。总平均年龄为 57±11 岁(范围:46-68 岁)。其中,43(27%)名患者的血糖在范围内,116(73%)名患者的血糖高于范围。在血糖超出范围的糖尿病患者中,54 人(47%)的葡萄糖钠转运受体功能亢进,62 人(53%)的葡萄糖钠转运受体功能正常。血糖在范围内的患者中,11 人(26%)的钠葡萄糖转运受体功能亢进,32 人(74%)的钠葡萄糖转运受体功能正常。钠葡萄糖转运受体的功能与血糖水平之间存在明显的关联(p 结论:钠葡萄糖转运受体功能障碍与血糖水平之间存在明显的关联:钠葡萄糖转运受体功能障碍会影响尿液中葡萄糖的分泌,导致 2 型糖尿病患者的血糖调节功能受损。
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引用次数: 0
Incidental Renal Infarction on imaging for Abdominal Aortic Aneurysm. 腹主动脉瘤造影中偶然发现的肾梗塞。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.24-93
Cevdet Donmez, Asma Bitar De Zayas-Enriquez, Hosny Hamza, Humayun Bashir

A 59-year-old man who under surveillance for abdominal aortic aneurysm and peripheral artery disease, was investigated with a CT Angiogram aorta. The CT scan showed an abdominal aortic aneurysm reaching 6.2cm with significant thrombus burden, occluded coeliac artery, occluded left iliac artery, calcified stenosis of the right renal artery and features of chronic renal infarct in the right upper pole. Technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) renal scan was done to document the extent of the infarction and for differential function of the kidneys.

一名 59 岁的男子因腹主动脉瘤和外周动脉疾病接受监护,接受了主动脉 CT 血管造影检查。CT 扫描显示,腹主动脉瘤达 6.2 厘米,血栓负担明显,腹腔动脉闭塞,左髂动脉闭塞,右肾动脉钙化狭窄,右上极有慢性肾梗塞的特征。对患者进行了锝-99m 二巯基丁二酸(Tc-99m DMSA)肾脏扫描,以确定梗死范围并鉴别肾脏功能。
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引用次数: 0
Unforeseen severity in a case of neonatal cow milk protein allergy: A case report. 一例新生儿牛奶蛋白过敏症的意外严重性:病例报告。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.11615
Alizeh Imran, Fatima Mustafa Lakdawala, Shahzaib Khan

Cow milk protein allergy (CMPA) is one of the most common childhood allergies that manifests with a range of digestive symptoms and skin reactions, which usually resolve with age. In this report, we present the case of a one-month-old male who presented with a rare and severe manifestation of neonatal CMPA. The neonate underwent numerous hospital admissions due to a presentation that closely mimicked symptoms of a metabolic disorder and sepsis. Our primary objective is to highlight the significance of systematically considering or excluding a CMPA diagnosis, irrespective of the severity of presentation. This proactive approach may potentially reduce future complications among the affected paediatric population, thereby preventing prolonged hospitalisation and the associated disease burden, as seen in this case.

牛奶蛋白过敏(CMPA)是最常见的儿童过敏症之一,表现为一系列消化道症状和皮肤反应,通常会随着年龄的增长而缓解。在本报告中,我们介绍了一例一个月大的男婴,他出现了罕见而严重的新生儿 CMPA 表现。该新生儿的表现与代谢紊乱和败血症的症状十分相似,因此多次入院治疗。我们的主要目的是强调,无论表现的严重程度如何,都要系统地考虑或排除 CMPA 诊断。这种积极主动的方法有可能减少受影响儿科人群未来的并发症,从而避免长期住院和相关疾病负担,就像本病例中看到的那样。
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引用次数: 0
Exploring the role of ketogenic diet in ADPKD treatment: A promising avenue. 探索生酮饮食在 ADPKD 治疗中的作用:一条充满希望的途径
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.20683
Abdul Mutaal, Dawood Shehzad, Khubaib Samdani
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引用次数: 0
Obesity Associated Reproductive and Sexual Syndrome(OARS) in Men. 男性肥胖相关生殖和性综合征(OARS)。
IF 0.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-01 DOI: 10.47391/JPMA.24-91
Sanjay Kalra, Atul Dhingra, Nitin Kapoor

Obesity, which has emerged as a major global public health challenge, is associated with myriad medical and multisystemic complications. Obesity impacts the male reproductive and sexual function in multiple ways as well. However, perhaps because of the focus on cardiovascular and metabolic health, the gonadal aspects of obesity medicine have not been given due attention. We propose the term OARS to describe obesity-associated reproductive and sexual syndrome in men living with obesity. OARS can be defined as a constellation of functional, hormonal, and structural abnormalities that affect the reproductive and sexual health of such men. The term OARS should attract attention to this neglected field and prompt efforts to prevent and address the needs of men living with obesity.

肥胖症已成为全球公共卫生的一大挑战,它与众多医疗和多系统并发症有关。肥胖症对男性生殖和性功能也有多方面的影响。然而,也许是因为人们把注意力集中在心血管和新陈代谢健康上,肥胖症医学的性腺方面尚未得到应有的重视。我们提出 OARS 一词来描述肥胖男性的肥胖相关生殖和性综合征。OARS 可定义为影响肥胖男性生殖和性健康的一系列功能、激素和结构异常。OARS 一词应引起人们对这一被忽视领域的关注,并促使人们努力预防和满足肥胖男性的需求。
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引用次数: 0
期刊
Journal of the Pakistan Medical Association
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