{"title":"Role of tight junctions in cell proliferation and cancer","authors":"Lorenza González-Mariscal, Susana Lechuga , Erika Garay","doi":"10.1016/j.proghi.2007.01.001","DOIUrl":null,"url":null,"abstract":"<div><p><span>The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/</span><em>β</em><span>-catenin complex in adherens junctions<span> during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.</span></span></p></div>","PeriodicalId":54550,"journal":{"name":"Progress in Histochemistry and Cytochemistry","volume":"42 1","pages":"Pages 1-57"},"PeriodicalIF":0.0000,"publicationDate":"2007-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.proghi.2007.01.001","citationCount":"129","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Histochemistry and Cytochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079633607000022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 129
Abstract
The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/β-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.
期刊介绍：
Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.
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