Chemical and physical regulation of stem cells and progenitor cells: potential for cardiovascular tissue engineering.

Ngan F Huang, Randall J Lee, Song Li
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引用次数: 29

Abstract

The field of cardiovascular tissue engineering has experienced tremendous advances in the past several decades, but the clinical reality of engineered heart tissue and vascular conduits remains immature. Stem cells and progenitor cells are promising cell sources for engineering functional cardiovascular tissues. To realize the therapeutic potential of stem cells and progenitor cells, we need to understand how microenvironmental cues modulate and guide stem cell differentiation and organization. This review describes the current understanding of the chemical and physical regulation of embryonic and adult stem cells for potential applications in cardiovascular repair, focusing on cardiac therapies after myocardial infarction and the engineering of vascular conduits.

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干细胞和祖细胞的化学和物理调控:心血管组织工程的潜力。
在过去的几十年里,心血管组织工程领域取得了巨大的进步,但工程心脏组织和血管导管的临床实践仍然不成熟。干细胞和祖细胞是具有工程功能的心血管组织的有前途的细胞来源。为了实现干细胞和祖细胞的治疗潜力,我们需要了解微环境线索如何调节和引导干细胞分化和组织。本文综述了胚胎干细胞和成体干细胞的化学和物理调控在心血管修复中的潜在应用,重点是心肌梗死后的心脏治疗和血管工程。
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来源期刊
Tissue engineering
Tissue engineering CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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Cartilage reshaping via in vitro mechanical loading. ECM molecules mediate both Schwann cell proliferation and activation to enhance neurite outgrowth. Development of custom-built bone scaffolds using mesenchymal stem cells and apatite-wollastonite glass-ceramics. Vascularized adipose tissue grafts from human mesenchymal stem cells with bioactive cues and microchannel conduits. A novel time-varying poly lactic-co glycolic acid external sheath for vein grafts designed under physiological loading.
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