A novel time-varying poly lactic-co glycolic acid external sheath for vein grafts designed under physiological loading.

Sophia W Liao, Xiao Lu, Andrew J Putnam, Ghassan S Kassab
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引用次数: 10

Abstract

Changes in dimensional and mechanical properties of degradable sheaths in poly lactic-co glycolic acid (PLGA) have been researched extensively. Composite PLGA having variable resorption rates in multiple layers under physiological loading has not been reported. Our novel design of a PLGA sheath is composed of 3 layers with different degradation rates (i.e., the innermost layer degrades the fastest, followed by the middle, while the outer layer degrades the slowest). In the presence of physiological luminal pressure, diameter is greater, thickness is less, resorption rate is greater, pore size is greater, and incremental modulus is greater than in nonpressurized sheaths. Furthermore, the ratio of the pore size to the sheath radius affects the dimensional changes of the sheath in the radial direction. In addition to changing the pore size-to-sheath radius ratio, the dimensional changes can be manipulated by choosing different glycolic and lactic acid ratios for the different layers. The application of this novel PLGA design for gradual arterialization of vein grafts is contemplated.

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生理负荷下新型时变聚乳酸-羟基乙酸静脉外鞘的设计。
人们对聚乳酸-乙醇酸(PLGA)中可降解护套的尺寸和力学性能变化进行了广泛的研究。复合PLGA在生理负荷下具有不同的多层吸收率尚未见报道。我们新设计的PLGA护套由3层不同降解速率组成(即最内层降解最快,中间层次之,外层降解最慢)。在生理管腔压力存在下,鞘层的直径更大,厚度更小,吸收速率更大,孔径更大,增量模量大于非加压鞘层。此外,孔隙大小与鞘层半径的比值影响了鞘层在径向上的尺寸变化。除了改变孔径与护套半径比外,还可以通过选择不同的乙醇酸和乳酸比例来控制尺寸的变化。这种新颖的PLGA设计应用于静脉移植物的逐渐动脉化。
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来源期刊
Tissue engineering
Tissue engineering CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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Cartilage reshaping via in vitro mechanical loading. ECM molecules mediate both Schwann cell proliferation and activation to enhance neurite outgrowth. Development of custom-built bone scaffolds using mesenchymal stem cells and apatite-wollastonite glass-ceramics. Vascularized adipose tissue grafts from human mesenchymal stem cells with bioactive cues and microchannel conduits. A novel time-varying poly lactic-co glycolic acid external sheath for vein grafts designed under physiological loading.
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