Design strategies of tissue engineering scaffolds with controlled fiber orientation.

Ramalingam Murugan, Seeram Ramakrishna
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引用次数: 403

Abstract

Tissue engineering is an emerging area of applied research with a goal of repairing or regenerating the functions of damaged tissue that fails to heal spontaneously by using cells and synthetic functional components called scaffolds. Scaffolds made of nanofibers (herein called "nano-fibrous scaffolds") play a key role in the success of tissue engineering by providing a structural support for the cells to accommodate and guiding their growth in the three-dimensional space into a specific tissue. The orientation of these fibers is considered as one of the important features of a perfect tissue scaffold, because the fiber orientation greatly influences cell growth and related functions. Therefore, engineering scaffolds with a control over fiber orientation is essential and a prerequisite for controlling cell orientation and tissue growth. Recent advances in electrospinning have made it possible to create nano-featured scaffolds with controlled fiber orientation. Electrospinning is a straightforward, cost-effective, and versatile method, which is recently applied in engineering well-defined nano-fibrous scaffolds that hold promise in serving as a synthetic extra-cellular matrix (ECM). This article reviews the current trends in electrospinning nano-fibrous scaffolds with fiber orientation. A detailed mechanism involved in the spinning process is discussed, followed by experimental examples that show how the fiber orientation influences cellular growth behavior. This review is expected to be useful for readers to gain knowledge on the state-of-the-art of scaffold engineering by electrospinning.

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控制纤维取向的组织工程支架设计策略。
组织工程是一个新兴的应用研究领域,其目标是通过使用细胞和称为支架的合成功能成分来修复或再生无法自发愈合的受损组织。纳米纤维支架(此处称为“纳米纤维支架”)为细胞提供结构支持,以容纳和引导细胞在三维空间中生长到特定的组织中,在组织工程的成功中起着关键作用。这些纤维的取向被认为是完美组织支架的重要特征之一,因为纤维的取向极大地影响细胞的生长和相关功能。因此,控制纤维取向的工程支架是控制细胞取向和组织生长的必要条件和前提。静电纺丝的最新进展使得制造具有纳米特征的纤维定向控制支架成为可能。静电纺丝是一种简单、经济、通用的方法,最近在工程中应用于定义明确的纳米纤维支架,有望作为合成细胞外基质(ECM)。本文综述了纤维取向静电纺丝纳米纤维支架的研究进展。讨论了纺丝过程的详细机理,并举例说明了纤维取向对细胞生长行为的影响。这篇综述希望对读者了解静电纺丝脚手架工程的最新进展有所帮助。
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来源期刊
Tissue engineering
Tissue engineering CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY
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