The question of heart failure in ONTARGET and TRANSCEND: implications for clinical practice.

José R González-Juanatey
{"title":"The question of heart failure in ONTARGET and TRANSCEND: implications for clinical practice.","authors":"José R González-Juanatey","doi":"10.1097/01.hjh.0000354518.90321.bb","DOIUrl":null,"url":null,"abstract":"<p><p>In patients with arterial hypertension and/or high cardiovascular risk, including patients with diabetes, chronic ischemic heart disease and kidney disease, the risk of heart failure decreases with blood pressure reduction and the use of drugs that inhibit the renin-angiotensin system (RAS) [angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)]. The heart failure incidence seen in ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) is in line with this observation. In ONTARGET, telmisartan and ramipril were equally effective in heart failure prevention and with the same blood pressure reduction. The low event rate, including the low incidence of heart failure in TRANSCEND with the greater use of diuretics in the placebo arm, may help to explain the absence of significant differences between telmisartan and placebo.</p>","PeriodicalId":16074,"journal":{"name":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension","volume":"27 2","pages":"S32-5"},"PeriodicalIF":0.0000,"publicationDate":"2009-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/01.hjh.0000354518.90321.bb","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of hypertension. Supplement : official journal of the International Society of Hypertension","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/01.hjh.0000354518.90321.bb","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

In patients with arterial hypertension and/or high cardiovascular risk, including patients with diabetes, chronic ischemic heart disease and kidney disease, the risk of heart failure decreases with blood pressure reduction and the use of drugs that inhibit the renin-angiotensin system (RAS) [angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs)]. The heart failure incidence seen in ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) is in line with this observation. In ONTARGET, telmisartan and ramipril were equally effective in heart failure prevention and with the same blood pressure reduction. The low event rate, including the low incidence of heart failure in TRANSCEND with the greater use of diuretics in the placebo arm, may help to explain the absence of significant differences between telmisartan and placebo.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
ONTARGET和TRANSCEND的心衰问题:对临床实践的影响。
在动脉性高血压和/或心血管高危患者中,包括糖尿病、慢性缺血性心脏病和肾病患者,随着血压降低和使用抑制肾素-血管紧张素系统(RAS)[血管紧张素转换酶抑制剂(ACEIs)和血管紧张素受体阻滞剂(ARBs)]的药物,心力衰竭的风险降低。正在进行的替米沙坦单独和联合雷米普利全球终点试验(ONTARGET)和替米沙坦随机评估研究(TRANSCEND)在ACE不耐受心血管疾病患者中的心衰发生率与这一观察结果一致。在ONTARGET试验中,替米沙坦和雷米普利在预防心力衰竭和降低血压方面同样有效。低事件发生率,包括在安慰剂组大量使用利尿剂的TRANSCEND组心衰发生率低,可能有助于解释替米沙坦和安慰剂之间没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects. Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. Hypertension and kidney alterations in rat offspring from low protein pregnancies.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1