Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects.

Iveta Bernatova, M Victoria Conde, Jana Kopincova, M Carmen González, Angelika Puzserova, Silvia M Arribas
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引用次数: 52

Abstract

Despite the apparent consensus on the existence of endothelial dysfunction in conduit and resistance arteries of spontaneously hypertensive rats (SHR), a commonly employed experimental model of hypertension, there are a number of reports showing that endothelium-dependent vasodilatory responses are similar, or even increased, in SHR compared with their normotensive counterparts. The present paper aims to discuss the rationale for these apparent discrepancies, including the effect of age, type of artery and methodological aspects. Data from the literature indicate that the age of the animal is a contributing factor and that endothelial dysfunction is likely to be a consequence of hypertension. In addition, the use of antioxidant additives, such as ascorbic acid or ethylene diaminetetraacetic acid, and differences in the level of initial arterial stretch, might also be of importance because they may modify the oxidative status of the artery and the levels of vasoactive factors released by the endothelium.

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自发性高血压大鼠内皮功能障碍:关注方法学方面。
自发性高血压大鼠(SHR)是一种常用的高血压实验模型,尽管在导管和阻力动脉中存在内皮功能障碍这一问题上存在明显的共识,但仍有许多报道显示,与正常高血压大鼠相比,SHR中内皮依赖性血管舒张反应相似,甚至增加。本文旨在讨论这些明显差异的基本原理,包括年龄,动脉类型和方法方面的影响。来自文献的数据表明,动物的年龄是一个促成因素,内皮功能障碍可能是高血压的后果。此外,抗氧化剂添加剂的使用,如抗坏血酸或乙二胺四乙酸,以及初始动脉拉伸水平的差异,可能也很重要,因为它们可能改变动脉的氧化状态和内皮细胞释放的血管活性因子的水平。
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