Practical aspects of treatment discontinuation and adherence.

Gianfranco Parati, Grzegorz Bilo
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引用次数: 4

Abstract

Hypertension control in populations, although improving, remains far from satisfactory, even though effective and inexpensive therapies are available. Among many factors responsible for this situation, poor adherence to treatment appears to be particularly important. Unfortunately, even if its causes have been quite well defined, this problem is still far from being solved in clinical practice. The present paper discusses the key issues related to treatment adherence, and discontinuation in hypertension, in the light of recent evidence coming from the ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial (ONTARGET) and Telmisartan Randomized AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease trial (TRANSCEND).

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停止治疗和坚持治疗的实际方面。
人群中的高血压控制虽然有所改善,但仍远不能令人满意,即使有有效和廉价的治疗方法。在造成这种情况的许多因素中,治疗依从性差似乎尤为重要。不幸的是,即使它的原因已经相当明确,这个问题在临床实践中仍远未得到解决。本文根据正在进行的替米沙坦单独和联合雷米普利全球终点试验(ONTARGET)和替米沙坦随机评估研究在ACE不耐受的心血管疾病患者试验(TRANSCEND)的最新证据,讨论了与高血压患者治疗依从性和停药相关的关键问题。
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