The role of nitric oxide in A3 adenosine receptor-mediated cardioprotection

A. Hussain, P. Karjian, H. Maddock
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引用次数: 6

Abstract

1 Limiting the impact of ischemia reperfusion-related cell death is of vital importance given the enormous figures of heart related mortality in the world.

2 Coronary heart disease (CHD) is responsible for over 100 000 deaths in the UK each year, and is the most common cause of premature death in the UK and as a whole it is estimated that there are just over 1.5 million men, and 1.1 million women, who have suffered CHD in the form of either angina or myocardial infarction (http://www.heartstats.org).

3 In patients undergoing standard clinical reperfusion treatment today such as thrombolysis, percutaneous coronary angioplasty (primary PCTA), and bypass surgery, there remains an underscored need for novel therapies and strategies to reduce post-ischemic infarct size.

4 This review focuses on some of the intracellular signalling pathways that have been proposed to be coupled to A3 adenosine receptors in order to reduce post-ischemic infarct size, in particular the role of nitric oxide in A3 adenosine receptor-mediated cardioprotection is discussed.

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一氧化氮在A3腺苷受体介导的心脏保护中的作用
1考虑到世界上心脏相关死亡率的巨大数字,限制缺血再灌注相关细胞死亡的影响至关重要。2冠心病(CHD)每年在英国造成超过10万人死亡,是英国过早死亡的最常见原因,总体而言,估计有超过150万男性和110万女性以心绞痛或心肌梗死的形式患有冠心病(http://www.heartstats.org)。在目前接受标准临床再灌注治疗的患者中,如溶栓、经皮冠状动脉成形术(原发性PCTA)和搭桥手术,仍然需要新的治疗方法和策略来减少缺血性梗死后的面积。这篇综述的重点是已经提出的一些细胞内信号通路与A3腺苷受体偶联,以减少缺血性梗死后的大小,特别是一氧化氮在A3腺苷受体介导的心脏保护中的作用被讨论。
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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