Angiotensin-II type 1 receptor (AT1R) and alpha-1D adrenoceptor form a heterodimer during pregnancy-induced hypertension

Autonomic and Autacoid Pharmacology Pub Date : 2010-06-09 DOI:10.1111/j.1474-8673.2009.00446.x

M. de Lourdes González-Hernández, D. Godínez-Hernández, R. A. Bobadilla-Lugo, P. López-Sánchez

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引用次数: 29

Abstract

1 Pregnancy courses with low response to angiotensin II and adrenergic agonists. In preeclampsia, both effects are reverted. It is known that angiotensin II regulates adrenergic system. It is not known, however, the interaction between both systems receptors.

2 Our aim was to study if AT₁R and α1D adrenoceptor heterodimerize in preeclampsia.

3 We used subrenal aorctic coarctation in pregnant rats. Aortic tissues were prepared for confocal imaging and coimmunoprecipitated for α1D and AT₁ receptors.

4 We found that AT₁R and α1D adrenoceptor heterodimerize in both, healthy and preeclamptic groups. In healthy pregnant rats, heterodimer is barely detected. In preeclamptic rats however, we found higher heterodimerization.

5 These results suggest that AT₁R and α1D -adrenoceptor may form heterodimers, and may play a role in preeclampsia.

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血管紧张素ii型1受体(AT1R)和α - 1d肾上腺素受体在妊娠高血压期间形成异源二聚体

妊娠期对血管紧张素II和肾上腺素激动剂反应低。在子痫前期，这两种作用都被逆转了。众所周知，血管紧张素II调节肾上腺素能系统。然而，这两个系统受体之间的相互作用尚不清楚。我们的目的是研究AT1R和α1D肾上腺素受体在子痫前期是否异二聚。我们采用妊娠大鼠肾下主动脉缩窄术。制备主动脉组织进行共聚焦成像，并对α1D和AT1受体进行共免疫沉淀。我们发现AT1R和α1D肾上腺素受体在健康组和子痫前期组中均存在异二聚体。在健康的怀孕大鼠中，几乎检测不到异二聚体。然而，在子痫前期大鼠中，我们发现较高的异源二聚化。这些结果提示AT1R与α1D -肾上腺素受体可能形成异源二聚体，并可能在子痫前期发挥作用。

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Autonomic and Autacoid Pharmacology

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