Self-Assembled Collagen-like Peptide Fibers as Templates for Metallic Nanowires.

Daniel Gottlieb, Stephen A Morin, Song Jin, Ronald T Raines
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Abstract

Inspired by nature's ability to fabricate supramolecular nanostructures from the bottom-up, materials scientist have become increasingly interested in the use of biomolecules like DNA, peptides, or proteins as templates for the creation of novel nanostructures and nanomaterials. Although the advantages of self-assembling biomolecular structures clearly lie in their chemical diversity, spatial control, and numerous geometric architectures, it is challenging to elaborate them into functional hybrid inorganic-bionanomaterials without rendering the biomolecular scaffold damaged or dysfunctional. In this study, attachment of gold nanoparticles to collagen-related self-assembling peptides at L-lysine residues incorportated within the peptides sequence and the N-terminus led to metal nanoparticle-decorated fibers. After electroless silver plating, these fibers were completely metalized, creating electrically conductive nanowires under mild conditions while leaving the peptide fiber core intact. This study demonstrates the bottom-up assembly of synthetic peptidic fibers under mild conditions and their potential as templates for other complex inorganic-organic hybrid nanostructures.

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作为金属纳米线模板的自组装胶原蛋白样肽纤维。
受大自然自下而上制造超分子纳米结构能力的启发,材料科学家对利用 DNA、肽或蛋白质等生物分子作为模板来制造新型纳米结构和纳米材料的兴趣日益浓厚。尽管自组装生物分子结构的优势明显在于其化学多样性、空间控制和多种几何结构,但要在不破坏生物分子支架或使其功能失调的情况下将其精心制作成功能性无机-生物混合材料却极具挑战性。在这项研究中,将金纳米粒子附着在胶原蛋白相关的自组装肽序列中的 L-赖氨酸残基和 N-末端,从而形成了金属纳米粒子装饰纤维。在无电解镀银后,这些纤维完全金属化,在温和条件下形成导电纳米线,而肽纤维内核却完好无损。这项研究展示了在温和条件下自下而上组装合成多肽纤维的过程,以及它们作为其他复杂的无机-有机杂化纳米结构模板的潜力。
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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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1.5 months
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