[STAT1: a many-sided transcription factor].

Bioorganicheskaia khimiia Pub Date : 2010-01-01
I A Kostanian, A V Vonarshenko, V M Lipkin
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Abstract

Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling systems is the STAT family, which is comprised of seven members. Various STATs operate as effective transcription factors delivering cytokine and growth factor signals to the nucleus. The first found and most studied member of this family is STAT1. This review summarizes modern data on the role of STAT1 in the maintenance of cellular homeostasis, and special attention is paid to this protein in the proliferation and apoptosis of immune system cell processes. It is shown that disturbances in the functionality of this molecule might contribute to oncogenesis.

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[STAT1:一种多侧转录因子]。
细胞稳态是由多种信号蛋白调控的。它们的主要任务是处理细胞外信号并激活导致基因活性调节的细胞内级联反应。其中一个重要的信号系统是STAT家族,它由七个成员组成。各种stat作为有效的转录因子将细胞因子和生长因子信号传递到细胞核。这个家族中最早被发现和研究最多的成员是STAT1。本文综述了STAT1在维持细胞稳态中的作用的现代数据,并特别关注该蛋白在免疫系统细胞过程中的增殖和凋亡。研究表明,对该分子功能的干扰可能有助于肿瘤的发生。
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