Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-04-01 DOI:10.1016/j.nano.2023.102664

Paula Muresan PhD , Stephen Woodhams PhD , Fiona Smith MPharm , Vincenzo Taresco PhD , Jaymin Shah PhD , Mei Wong PhD , Victoria Chapman PhD , Stuart Smith MD, PhD , Gareth Hathway PhD , Ruman Rahman PhD , Pavel Gershkovich PhD , Maria Marlow PhD

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引用次数: 1

Abstract

We investigated how the biodistribution of cannabidiol (CBD) within the central nervous system (CNS) is influenced by two different formulations, an oil-in-water (O/W) nanoemulsion and polymer-coated nanoparticles (PCNPs). We observed that both CBD formulations administered were preferentially retained in the spinal cord, with high concentrations reaching the brain within 10 min of administration. The CBD nanoemulsion reached C_max in the brain at 210 ng/g within 120 min (T_max), whereas the CBD PCNPs had a C_max of 94 ng/g at 30 min (T_max), indicating that rapid brain delivery can be achieved through the use of PCNPs. Moreover, the AUC₀_–₄ _h of CBD in the brain was increased 3.7-fold through the delivery of the nanoemulsion as opposed to the PCNPs, indicating higher retention of CBD at this site. Both formulations exhibited immediate anti-nociceptive effects in comparison to the respective blank formulations.

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评估大麻二酚纳米颗粒和纳米乳在鞘内给药治疗疼痛后中枢神经系统的生物分布

我们研究了大麻二酚(CBD)在中枢神经系统(CNS)中的生物分布如何受到两种不同配方的影响，一种是水包油(O/W)纳米乳液，另一种是聚合物包覆纳米颗粒(PCNPs)。我们观察到，给药的两种CBD配方都优先保留在脊髓中，高浓度在给药后10分钟内到达大脑。CBD纳米乳在120分钟内达到210 ng/g的Cmax (Tmax)，而CBD PCNPs在30分钟内达到94 ng/g的Cmax (Tmax)，表明通过使用PCNPs可以实现快速脑递送。此外，与PCNPs相比，通过纳米乳的递送，CBD在大脑中的AUC0-4 h增加了3.7倍，表明CBD在该部位的保留率更高。与空白配方相比，两种配方均表现出直接的抗伤害性效果。

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来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.