F Azizi, Q Wan, T Radivoyevitch, C Dealwis, C H Mastrangelo
{"title":"A combinatorial multicomponent plug mixer for systems chemistry.","authors":"F Azizi, Q Wan, T Radivoyevitch, C Dealwis, C H Mastrangelo","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>We report the construction and testing of a combinatorial multicomponent plug mixer (CMPM) chip that generates a large number of mix ratios. The CMPM chip has been designed to study ribonucleotide reductase (RNR) protein-protein/protein-ligand interaction networks. The 4-component chip is capable of 5400 different combinations in a 30 plug cycle. CMPM chips were tested producing fluorescent dye and dihydrofolate reductase NADPH/MX mixtures with plug lengths of 2 mm.</p>","PeriodicalId":88936,"journal":{"name":"Micro total analysis systems : proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference)","volume":"2008 ","pages":"1904-1906"},"PeriodicalIF":0.0000,"publicationDate":"2008-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857516/pdf/nihms144931.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Micro total analysis systems : proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference)","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We report the construction and testing of a combinatorial multicomponent plug mixer (CMPM) chip that generates a large number of mix ratios. The CMPM chip has been designed to study ribonucleotide reductase (RNR) protein-protein/protein-ligand interaction networks. The 4-component chip is capable of 5400 different combinations in a 30 plug cycle. CMPM chips were tested producing fluorescent dye and dihydrofolate reductase NADPH/MX mixtures with plug lengths of 2 mm.
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