Effects of long-term treatment with fluoxetine and venlafaxine on rat isolated vas deferens

S. S. Göçmez, T. Utkan, G. Ulak, N. Gacar, F. Erden
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引用次数: 16

Abstract

1 Antidepressant therapy is considered as one of the factors leading to male infertility.

2 In this study, the effects of long-term treatment with fluoxetine or venlafaxine were investigated on electrical field stimulation (EFS, 1–64 Hz), noradrenaline (10−8 to 10−4m), serotonin (10−8 to 10−4m), adenosine 5′-triphosphate [ATP (10−8 to 10−4m)] and 80 mm KCl-induced contractile responses in the epididymal and prostatic portions of rat isolated vas deferens strips.

3 Serotonin-induced contractile responses were significantly increased in the epididymal portion of the vas deferens obtained from the fluoxetine-treatment group, whereas in the prostatic portion there was no change. However, venlafaxine treatment had no effect on serotonin responses in the either portion of the vas deferens. Both fluoxetine and venlafaxine treatment significantly inhibited ATP-evoked contractions of the prostatic and epididymal portions of the rat vas deferens, but had no effect on EFS, noradrenaline- and KCl-evoked contractions of the vas deferentia in both portions.

4 In conclusion, these results suggest that chronic treatment with fluoxetine and venlafaxine affects vas deferens motility. Purinoceptors may, at least in part, responsible for the impaired motility in chronic treatment of venlafaxine and fluoxetine.

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氟西汀和文拉法辛长期治疗对大鼠离体输精管的影响
抗抑郁治疗被认为是导致男性不育的因素之一。在这项研究中,研究了氟西汀或文拉法辛长期治疗对电场刺激(EFS, 1-64 Hz)、去甲肾上腺素(10−8至10−4 m)、血清素(10−8至10−4 m)、腺苷5′-三磷酸[ATP(10−8至10−4 m)]和80 mm氯化钾诱导的大鼠离体输精管条附睾和前列腺部分的收缩反应的影响。氟西汀治疗组输精管附睾部分血清素诱导的收缩反应明显增加,而前列腺部分没有变化。然而,文拉法辛治疗对输精管两部分的血清素反应没有影响。氟西汀和文拉法辛治疗均能显著抑制atp诱导的大鼠输精管前列腺和附睾部分的收缩,但对EFS、去甲肾上腺素和kcl诱导的输精管两部分的收缩无影响。综上所述,这些结果表明氟西汀和文拉法辛慢性治疗影响输精管运动。嘌呤受体可能,至少部分地,对文拉法辛和氟西汀慢性治疗中的运动障碍负责。
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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