Abstract from the 41st Nordic Gastroenterology Congress, 8-11 June 2010, Copenhagen, Denmark.

Abstract

Book List of content Invited Speaker Abstracts 28 Free paper abstracts 45 Nurse programme invited speaker abstracts 61 Nurse programme oral presentation abstracts 64 Poster presentation abstracts 66 Postgraduate course abstracts 87 Session Chair abstracts 90 Author Index 91 Invited Speaker abstracts Interventional oncology in liver metastases Sat 1 Vogl, Thomas University Hospital of Frankfurt, Frankfurt, Germany Minimal-invasive therapies for tumor treatment in solid organs like liver or lung are based on different intravascular techniques (e.g. transarterial chemoembolization (TACE)) or thermal techniques (e.g. laser-induced thermotherapy (LITT)). In contrast to systemic chemotherapy local chemotherapy can be injected in the tumor area in a concentration up to 100 times higher with fewer side effects. Besides, selective ischemia and tumor starvation are caused by embolizing the branches of the hepatic artery. Under local anaesthesia the femoral artery is punctured in the inguinal region followed by insertion of a femoral sheath. The latter allows free exchange of catheters without vessel wall injury while bleeding is prevented. After identifying the hepatic artery the catheter is advanced into the aorta. A small catheter is passed through the hepatic artery into the tumor-supplying artery and chemoembolization is locally injected in the tumor followed by an embolizing material. After removing catheters/sheath, a small suture is prepared to prevent bleeding at the puncture site. The patient is then observed for 4-6h during which complications can be diagnosed and treated. To monitor treatment success and rule out complications, unenhanced CT is performed post procedure. Typically 2-3 TACE sessions in 4-week intervals are necessary. Tumor response is determined 4 weeks later by MRI. LITT is a minimal-invasive technique for local tumor destruction in solid organs using laser light. The laser (Nd:YAG laser (1,064nm)) is exactly targeted on the tissue volume. Due to the comparably high penetrability of photons and complication-free transfer of energy through guide-light, laser of near-infrared region (NIR) is used. The energy is applied to the target tissue using special laser applicators. Laser light energy is absorbed, which causes heating and thus coagulation of the tumor tissue. To benefi t from the advantages of the effect and accuracy of the therapy, all factors contributing to the therapy success must be fi ne-tuned by calculating duration and output of the laser. Depending on size, number and location of the lesion more laser applicators and more cycles of therapy may be required. In practice a temperature of about 60-110°C is achieved in the tumor tissue. Challenges in combating the obesity epidemic Inv 01 Sorensen, Thorkild IA Bispebjerg University Hospital, Institute of Preventive Medicine, Copenhagen, Denmark Background: An obesity epidemic has developed worldwide, even in less developed and poor countries. The epidemic creates a new serious burden to the health of the populations because of its concurrent psychosocial and somatic handicaps and the increased risk of a broad panel of diseases, including type 2 diabetes, hypertension, cardiovascular diseases, some cancers, NAFLD, gallstones and osteoarthitis as prominent ones. The more severe the obesity, the higher is the mortality; it is now expected that the overall life expectations of the populations most affected may decline in the near future. There is therefore a very strong demand to fi nd ways to combat the epidemic. Methods: While it is impossible to solve the health problems induced by the epidemic by treatment of those already obese with the tools currently available for clinical use (behavioural modifi cations, restrictions in caloric intake, antiobesity drugs, bariatric surgery), a critical review of the evidence for what has caused the epidemic is needed to fi nd ways of preventing development of obesity. If these causes are still operating in maintaining already developed obesity and if they are reversible, this undertaking may also provide treatment targets. Results: The obesity epidemic is obviously caused by some changes in the environment, which may interact with or