Effects of repeated maprotiline and fluoxetine treatment on gene expression of catecholamine synthesizing enzymes in adrenal medulla of unstressed and stressed rats

N. Spasojevic, L. Gavrilovic, S. Dronjak
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引用次数: 18

Abstract

1 Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of catecholamine biosynthetic enzymes were examined in adrenal medulla of unstressed control and chronic unpredictable mild stressed rats.

2 Maprotiline did not change gene expression of catecholamine biosynthetic enzymes in control and stressed rats.

3 Fluoxetine increased gene expression of tyrosine hydroxylase (TH) and dopamine-β-hydroxylase (DBH), but did not phenylethanolamine N-methyltransferase in both unstressed and chronic unpredictable mild stressed animals.

4 In conclusion, we have demonstrated that repeated administration of fluoxetine enhanced gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in adrenal medulla of control and stressed rats.

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马普替林和氟西汀对应激大鼠肾上腺髓质儿茶酚胺合成酶基因表达的影响
研究了马普替林(一种去甲肾上腺素再摄取抑制剂)和氟西汀(一种血清素再摄取抑制剂)对非应激对照和慢性不可预测轻度应激大鼠肾上腺髓质儿茶酚胺生物合成酶基因表达的影响。2 .马普替林对对照组和应激大鼠儿茶酚胺生物合成酶基因表达无影响。3氟西汀增加了非应激和慢性不可预测轻度应激动物酪氨酸羟化酶(TH)和多巴胺-β-羟化酶(DBH)的基因表达,但对苯乙醇胺n -甲基转移酶没有影响。综上所述,我们已经证明,反复给药氟西汀增强了TH和DBH的基因转录,随后刺激了对照组和应激大鼠肾上腺髓质中去甲肾上腺素的合成。
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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