A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children--melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a "suffocation" product.

Q2 Medicine BMC Dermatology Pub Date : 2010-08-20 DOI:10.1186/1471-5945-10-6

Stephen C Barker, Phillip M Altman

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引用次数: 49

Abstract

Background: There are many different types of pediculicides available OTC in Australia. In this study we compare the efficacy and safety of three topical pediculicides: a pediculicide containing melaleuca oil (tea tree oil) and lavender oil (TTO/LO); a head lice "suffocation" product; and a product containing pyrethrins and piperonyl butoxide (P/PB).

Method: This study was a randomised, assessor-blind, comparative, parallel study of 123 subjects with live head lice. The head lice products were applied according to the manufacturer's instructions (the TTO/LO product and the "suffocation" product were applied three times at weekly intervals according to manufacturers instructions (on Day 0, Day 7 and Day 14) and the P/PB product was applied twice according to manufacturers instructions (on Day 0 and Day 7)). The presence or absence of live lice one day following the last treatment was determined.

Results: The percentage of subjects who were louse-free one day after the last treatment with the product containing tea tree oil and lavender oil (41/42; 97.6%) and the head lice "suffocation" product (40/41, 97.6%) was significantly higher compared to the percentage of subjects who were louse-free one day after the last treatment with the product containing pyrethrins and piperonyl butoxide (10/40, 25.0%; adj. p < 0.0001).

Conclusion: The high efficacy of the TTO/LO product and the head lice "suffocation" product offers an alternative to the pyrethrins-based product.

Trial registration: The study was entered into the Australian/New Zealand Clinical Trial Registry, ACTRN12610000179033.

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一项随机、评估盲、平行组比较三种治疗儿童头虱产品的疗效试验——千层油和薰衣草油、除虫菊酯和胡椒酰丁醇，以及一种“窒息”产品。

背景:在澳大利亚有许多不同类型的OTC杀虱剂。在这项研究中，我们比较了三种外用杀蒂剂的疗效和安全性:一种是含有千层油(茶树油)和薰衣草油(TTO/LO)的杀蒂剂;头虱“窒息”产品;以及含有除虫菊酯和胡椒酰丁醇(P/PB)的产品。方法:本研究采用随机、评估盲、比较、平行研究，纳入123例活头虱患者。头虱产品按照生产商说明涂抹(TTO/LO产品和“窒息”产品按照生产商说明每周涂抹三次(第0天、第7天和第14天)，P/PB产品按照生产商说明涂抹两次(第0天和第7天))。最后一次治疗后一天是否存在活虱。结果:茶树精油和薰衣草精油产品末次治疗后1天无虱子的受试者百分比(41/42;97.6%)和头虱“窒息”产品(40/41,97.6%)显著高于最后一次使用含除虫菊酯和胡椒酰丁醇产品1天后无虱的受试者比例(10/40,25.0%;p < 0.0001)。结论:TTO/LO产品和头虱“窒息”产品具有较高的功效，可替代以除虫菊酯为基础的产品。试验注册:该研究已进入澳大利亚/新西兰临床试验注册中心，编号为ACTRN12610000179033。

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BMC Dermatology Medicine-Dermatology

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期刊介绍： BMC Dermatology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of skin disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Dermatology (ISSN 1471-5945) is indexed/tracked/covered by PubMed, MEDLINE, CAS, EMBASE, Scopus and Google Scholar.