Associations of self-reported atopic dermatitis with comorbid conditions in adults: a population-based cross-sectional study.

Q2 Medicine BMC Dermatology Pub Date : 2020-12-17 DOI:10.1186/s12895-020-00117-8

Jevgenija Smirnova, Scott Montgomery, Magnus Lindberg, Åke Svensson, Laura von Kobyletzki

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引用次数: 17

Abstract

Background: The objective of this study was to investigate the relationships between atopic dermatitis (AD) and other common chronic health conditions in adults.

Methods: A cross-sectional survey was sent to a randomly selected population sample of 78,004 adults in Sweden. The questionnaires included measures of self-reported physical and mental health. Binary and multinomial logistic regression were used to examine the associations of AD with common chronic health conditions and psychological wellbeing.

Results: AD was self-reported by 4,175 respondents, representing almost 14% of the study population of 34,313 adults. Our results showed positive associations between AD and chronic health disorders, including conditions of the oral cavity: chronic obstructive pulmonary disease (adjusted odds ratio [aOR] = 1.58, 95% confidence interval [CI]: 1.30 to 1.92), asthma (aOR = 2.13, 95% CI: 1.91 to 2.38), mild recurrent gastrointestinal symptoms (adjusted relative risk ratio [aRRR] = 1.78, 95% CI: 1.64 to 1.92), high blood pressure (aOR = 1.16, 95% CI: 1.06 to 1.26), obesity (aOR = 1.34, 95% CI: 1.23 to 1.47), mild joint pain (aRRR = 1.47, 95% CI: 1.35 to 1.61), mild headache or migraine (aRRR = 1.50, 95% CI: 1.38 to 1.64), caries (aOR = 1.25, 95% CI: 1.04 to 1.49), bleeding gums (aOR = 1.69, 95% CI: 1.38 to 2.08), periodontitis (aOR = 1.42, 95% CI: 1.13 to 1.77), sensitive teeth (aOR = 1.57, 95% CI: 1.35 to 1.82), and dry mouth (aOR = 1.52, 95% CI: 1.33 to 1.74). Adjustment for asthma and depression attenuated the magnitude of the associations between AD and the study outcomes. AD was also associated with poorer general psychological wellbeing.

Conclusions: Adults reporting AD may be at increased risk of chronic disorders and decreased psychological wellbeing. Physicians should recognize that individuals with severe AD and those with comorbid asthma or depression may be especially vulnerable.

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成人中自我报告的特应性皮炎与合并症的关联:一项基于人群的横断面研究

背景:本研究的目的是探讨成人特应性皮炎(AD)与其他常见慢性健康状况之间的关系。方法:对瑞典随机抽取的78,004名成年人进行横断面调查。调查问卷包括自我报告的身体和心理健康状况。使用二元和多项逻辑回归来检查AD与常见慢性健康状况和心理健康的关系。结果:4175名受访者自我报告AD，占34,313名成年人研究人群的近14%。我们的研究结果显示AD与慢性健康疾病呈正相关，包括口腔疾病:慢性阻塞性肺病(校正优势比[aOR] = 1.58, 95%可信区间[CI]: 1.30至1.92)、哮喘(aOR = 2.13, 95% CI: 1.91至2.38)、轻度复发性胃肠道症状(校正相对风险比[aRRR] = 1.78, 95% CI: 1.64至1.92)、高血压(aOR = 1.16, 95% CI: 1.06至1.26)、肥胖(aOR = 1.34, 95% CI:1.23 ~ 1.47)，轻度关节痛(aRRR = 1.47, 95% CI: 1.35 ~ 1.61)，轻度头痛或偏头痛(aRRR = 1.50, 95% CI: 1.38 ~ 1.64)，龋齿(aOR = 1.25, 95% CI: 1.04 ~ 1.49)，牙龈出血(aOR = 1.69, 95% CI: 1.38 ~ 2.08)，牙周炎(aOR = 1.42, 95% CI: 1.13 ~ 1.77)，敏感牙(aOR = 1.57, 95% CI: 1.35 ~ 1.82)，口干(aOR = 1.52, 95% CI: 1.33 ~ 1.74)。对哮喘和抑郁症的调整降低了AD与研究结果之间的相关性。阿尔茨海默病还与较差的总体心理健康状况有关。结论:报告阿尔茨海默氏症的成年人患慢性疾病的风险可能增加，心理健康水平可能下降。医生应该认识到，患有严重阿尔茨海默病和合并哮喘或抑郁症的人可能特别容易受到伤害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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BMC Dermatology Medicine-Dermatology

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期刊介绍： BMC Dermatology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of skin disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Dermatology (ISSN 1471-5945) is indexed/tracked/covered by PubMed, MEDLINE, CAS, EMBASE, Scopus and Google Scholar.