Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat.

Methods and findings in experimental and clinical pharmacology Pub Date : 2010-12-01 DOI:10.1358/mf.2010.32.10.1522224

R Prasad, M Naime, I Routray, A Mahmood, F Khan, S Ali

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引用次数: 12

Abstract

Valeriana jatamansi (family, Valerianaceae) is a traditional medicinal herb in the Indian subcontinent. This study provides experimental evidence indicating the therapeutic effect of the extract prepared from the dried rhizome of the herb in an animal model of liver cirrhosis and on cell proliferation. Liver cirrhosis was induced in rats by thioacetamide (0.03% in drinking water for 16 weeks). After inducing liver cirrhosis, rats were administered the extract orally for 9 weeks. Treatment was found to partially reverse the elevated levels of alkaline phosphatase, γ-glutamyl transferase and selected biochemical markers of hepatic injury including drug-metabolizing enzymes. Histopathology of the hepatic tissue confirmed the therapeutic effect of the extract which corroborated with the biochemical changes. The extract is also reported to ameliorate hepatic cell proliferation in rats injected with thioacetamide. The study has implications in finding a treatment for liver cirrhosis in humans.

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缬草部分逆转大鼠肝硬化和组织增生性反应。

缬草(缬草科)是印度次大陆的传统草药。本研究提供了实验证据，证明了该草药干燥根茎提取物对肝硬化动物模型的治疗作用和对细胞增殖的影响。硫乙酰胺(0.03%)灌胃16周后诱导大鼠肝硬化。诱导肝硬化后，大鼠口服提取物9周。研究发现，治疗可以部分逆转碱性磷酸酶、γ-谷氨酰转移酶和肝损伤生化指标(包括药物代谢酶)升高的水平。肝组织病理学证实了提取物的治疗效果，并证实了其生化变化。据报道，该提取物还能改善大鼠注射硫乙酰胺后肝细胞的增殖。这项研究对寻找治疗人类肝硬化的方法具有启示意义。

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Methods and findings in experimental and clinical pharmacology 医学-药学

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