Ontology mapping and data discovery for the translational investigator.

Rob Wynden, Mark G Weiner, Ida Sim, Davera Gabriel, Marco Casale, Simona Carini, Shannon Hastings, David Ervin, Samson Tu, John H Gennari, Nick Anderson, Ketty Mobed, Prakash Lakshminarayanan, Maggie Massary, Russ J Cucina
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Abstract

An integrated data repository (IDR) containing aggregations of clinical, biomedical, economic, administrative, and public health data is a key component of an overall translational research infrastructure. But most available data repositories are designed using standard data warehouse architecture that employs arbitrary data encoding standards, making queries across disparate repositories difficult. In response to these shortcomings we have designed a Health Ontology Mapper (HOM) that translates terminologies into formal data encoding standards without altering the underlying source data. We believe the HOM system promotes inter-institutional data sharing and research collaboration, and will ultimately lower the barrier to developing and using an IDR.

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翻译研究者的本体映射和数据发现。
包含临床、生物医学、经济、行政和公共卫生数据集合的集成数据存储库(IDR)是整个转化研究基础设施的关键组成部分。但是,大多数可用的数据存储库都是使用使用任意数据编码标准的标准数据仓库架构设计的,这使得跨不同存储库的查询变得困难。针对这些缺点,我们设计了一个健康本体映射器(Health Ontology Mapper, HOM),它可以在不改变底层源数据的情况下将术语转换为正式的数据编码标准。我们相信,HOM系统促进了机构间的数据共享和研究合作,并将最终降低开发和使用IDR的障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Analysis of eligibility criteria complexity in clinical trials. The human studies database project: federating human studies design data using the ontology of clinical research. Analysis of False Positive Errors of an Acute Respiratory Infection Text Classifier due to Contextual Features. An R package for simulation experiments evaluating clinical trial designs. Ontology mapping and data discovery for the translational investigator.
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