The role of the microenvironment in tumor immune surveillance.

IF 1.9 Bioinformation Pub Date : 2011-01-06 DOI:10.6026/97320630005285
Oluwadayo Oluwadara, Luca Giacomelli, Xenia Brant, Russell Christensen, Raisa Avezova, George Kossan, Francesco Chiappelli
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引用次数: 12

Abstract

The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.

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微环境在肿瘤免疫监测中的作用。
有令人信服的证据表明,微环境以及相关的生物细胞和分子因素可能促进多种肿瘤的进展。微环境的影响可能直接影响T细胞系的可塑性,这一点最近得到了讨论(O’shea & Paul, 2010[4])。为了回顾微环境在调节肿瘤免疫监视承诺中的假定作用,我们使用口腔癌前病变模型。
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Bioinformation
Bioinformation MATHEMATICAL & COMPUTATIONAL BIOLOGY-
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