Oluwadayo Oluwadara, Luca Giacomelli, Xenia Brant, Russell Christensen, Raisa Avezova, George Kossan, Francesco Chiappelli
{"title":"The role of the microenvironment in tumor immune surveillance.","authors":"Oluwadayo Oluwadara, Luca Giacomelli, Xenia Brant, Russell Christensen, Raisa Avezova, George Kossan, Francesco Chiappelli","doi":"10.6026/97320630005285","DOIUrl":null,"url":null,"abstract":"<p><p>The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.</p>","PeriodicalId":8962,"journal":{"name":"Bioinformation","volume":"5 7","pages":"285-90"},"PeriodicalIF":1.9000,"publicationDate":"2011-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043348/pdf/","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioinformation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6026/97320630005285","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
The evidence appears compelling that the microenvironment, and associated biological cellular and molecular factors, may contribute to the progression of a variety of tumors. The effects of the microenvironment may directly influence the plasticity of T cell lineages, which was recently discussed (O'Shea & Paul, 2010 [4]). To review the putative role of the microenvironment in modulating the commitment of tumor immune surveillance, we use the model of oral premalignant lesions.