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The relationship between Class II amalgam restorations and alveolar bone loss among diabetic and non-diabetic patients is evaluated at the Faculty of Dentistry, Najran University, KSA. Hence, we compared type 2 diabetic (n = 32) and non-diabetic patients (n=32) using clinical assessments and imaging techniques. Parameters such as bone loss rate, extent, age, and periodontal condition (plaque index and Gingival Index) were analyzed. Analysis of data shows that diabetic patients on average have higher bone loss.

Omics studies use large-scale high-throughput data to explain changes underlying different traits or conditions. However, omics analysis often results in long lists of pathways that are difficult to interpret. Therefore, it is of interest to describe a tool named PAVER (Pathway Analysis Visualization with Embedding Representations) for large scale genomic analysis. PAVER curates similar pathways into groups, identifies the pathway most representative of each group, and provides publication-ready intuitive visualizations. PAVER clusters pathways defined by their vector embedding representations and then identifies the term most cosine similar to its respective cluster's average embedding. PAVER can integrate multiple pathway analyses, highlight relevant biological insights, and work with any pathway database.

Shatavari (Asparagus racemosus) has been used for female health problems since ancient times and is useful for treating various female reproductive problems including menopausal problems, hormonal imbalance, lactation, menstrual issues, and others. Shatavarins, the primary phytoconstituents of Shatavari, have high molecular weights and may interact with hormone receptors. We have conducted a molecular docking analysis for different Shatavarins such as Shatavarin I, Shatavarin IV, Shatavarin VI, Shatavarin VII, Shatavarin VIII, Shatavarin IX, and Shatavarin X with different hormonal receptors such as estrogen alpha, beta, and gamma receptor, progesterone receptor, FSH, and LH receptors. The best docking conformations with the highest docking scores, specific interactions and bond formations, and the most important residues of the receptors were identified and reported. The study was successful in providing an initial comparative insight into the binding efficiencies of the Shatavarins for different female hormonal receptors.

Silver diamine fluoride (SDF) is a highly effective topical fluoride for halting dental caries; however, it darkens both teeth and restorations. Therefore, it is of interest to assess the shear bond strength (SBS) of glass ionomer cement (GIC) to caries-affected dentin treated with SDF alone and SDF followed by KI. Forty primary molar samples were prepared to reveal a flat dentin surface and were randomly assigned to two groups. In group A, the dentin surfaces were pre-treated with 38% SDF, while in group B, the dentin was treated first with SDF and then with KI before being restored with GIC. The SBS was measured using a universal testing machine. The results show that teeth pre-treated with both SDF and KI demonstrated significantly improved bond strength of GIC to dentin compared to SDF treatment alone.

Adolescent girls face myriad challenges impacting their mental health and well-being, necessitating empowerment through self-defense education. In contexts of prevalent gender-based violence, such education becomes imperative, particularly in countries like India. However, the influence of demographic factors on knowledge levels regarding self-defense techniques among adolescent girls remains uncertain. This study employed a one-group pre-test - post-test design to evaluate the impact of a video-assisted self-defense teaching program on adolescent girls in rural Gujarat, India. A sample of 100 girls from Mahesana district schools participated, with data collected via structured questionnaires administered pre and post-intervention. The intervention significantly enhanced participants' knowledge levels, with a remarkable increase in mean post-test scores compared to pre-test scores. Specifically, prior to the intervention, 45% of participants exhibited low knowledge levels, which improved to 19.5% post-intervention. Notably, 80.5% demonstrated excellent knowledge post-intervention. The study underscores the efficacy of a video-assisted self-defense teaching program in augmenting knowledge levels among adolescent girls in rural Gujarat. Despite demographic diversity, the intervention yielded consistent improvements, emphasizing its universal applicability.

Tobacco chewing remains a prevalent health issue globally, particularly in India, where it is deeply ingrained in cultural practices. This study evaluates the impact of a structured teaching program on knowledge regarding the ill effects of tobacco chewing among adults enrolled in arts and commerce colleges in Patan, India. A quasi-experimental design was employed, with 100 participants recruited from arts and commerce colleges. The structured teaching program included educational sessions covering the harmful effects of tobacco chewing and cessation strategies. Pre and post-test knowledge assessments were conducted using a self-structured questionnaire. The majority of participants were aged 15-17 years (75%), male (75%), and from urban areas (58.33%). Significant improvements in knowledge scores were observed following the intervention (pretest mean score = 11.5, posttest mean score = 44.38), with a significant difference between pre and post-test scores (t = 11.38, p < 0.001). Associations between pre-test knowledge scores and demographic variables such as gender, education, type of family, area of residence, father's education and occupation, monthly income, history of illness, and previous knowledge were identified (p < 0.05). Conclusion: The study underscores the significance of targeted health education programs in addressing tobacco-related health risks and promoting public health. By enhancing awareness and knowledge among adults, such interventions contribute to fostering behavior change and reducing the burden of tobacco-related diseases.

The administration of local anesthesia constitutes one of the most anxiety-inducing and painful stimuli in pediatric dentistry. Therefore, it is of interest to evaluate the effectiveness of vibrating device in comparison to the conventional method for mitigating discomfort while administration of local anesthesia. A total of 30 children aged between 6 and 10 years, requiring local anesthesia for routine dental treatment, were allocated into two groups: a control group and an experimental group, with 15 children in each cohort. In the experimental group, a vibrating device was concurrently placed over the cheek during the administration of the local anesthesia. Pain and discomfort were assessed using both the Wong-Baker FACES Pain Rating Scale (WBFPRS) and the FLACC (Face, Legs, Activity, Cry, CONSOL ability) scale. It was observed that use of the vibrating device was found to be effective in reducing pain and discomfort during the administration of intraoral local anesthesia.

Cardiovascular diseases (CVDs) are a group of disorders that affect the heart and blood vessels. Identifying high-risk individuals is a primary goal of cardiovascular disease prevention. The aim is to examine risk factor on assessing lipid profiles and blood pressure, both in obese and non-obese individuals. This study took place over a year at a Tertiary Care Hospital, were investigated the lipid profile and blood pressure of obese and non-obese participants aged 30-60 years. The obese group had an average age of 43.2±6.3 years compared to 45.1±5.8 years in the non-obese group, indicating a slightly older population in the obese group. The non-obese group had an average total cholesterol level of 193.7 mg/dL, with a total cholesterol (TC) level of 209.3 mg/dL. When it came to LDL cholesterol, the obese group had a higher level of 137.4 mg/dL compared to the non-obese group with 121.3 mg/dL. Conversely, HDL cholesterol levels were lower in the obese group at 44.1 mg/dL than in the non-obese group at 49.1 mg/dL. Obesity is associated with lipid metabolism and hypertension disturbances, especially with effect on HDL-C reduction and TC, TG, LDL cholesterol to high level. Thus, lipid profile and blood pressure among obese and non-obese individuals help in cardiovascular risk evaluation.

The smear layer removal capability of different instrumentation techniques on the mesio-buccal root canals of maxillary first molars is of interest to dentists. Sixty extracted maxillary first molars with fully developed apices, curved root canals, and curvatures between 30 to 45 degrees were selected. The teeth were divided into four groups (n=15) based on the instrumentation technique used. The samples were analyzed using a thermal field emission scanning electron microscope to assess smear layer removal at the apical, middle, and coronal thirds of the canals. The Wave One file system showed superior performance in smear layer removal across all three regions of the canal compared to hand files, Hyflex CM rotary files and SAF.

Biomimetic scaffold and 3D bioprinting technologies have emerged as promising avenues in tissue engineering and regenerative medicine, offering innovative approaches to address the limitations of conventional tissue engineering methods. This review article provides a comprehensive overview of recent advancements, challenges, and future prospects in the field of biomimetic scaffold fabrication and 3D bioprinting techniques.