{"title":"Ca2+/calmodulin-dependent protein kinase II in heart failure","authors":"Howard Schulman , Mark E. Anderson","doi":"10.1016/j.ddmec.2010.07.005","DOIUrl":null,"url":null,"abstract":"<div><p>Ca<sup>2+</sup>/calmodulin (CaM)-dependent protein kinase II (CaMKII) is now recognized to play a central role in myocardial biology and disease. CaMKII appears to grade myocardial performance and regulate heart rate by catalyzing the phosphorylation of major proteins involved in cardiac excitation-contraction coupling. Under pathological stress, CaMKII activates hypertrophic and inflammatory transcriptional pathways and promotes apoptosis. Animal studies suggest that CaMKII inhibition may be an effective approach for treating common forms of structural heart disease.</p></div>","PeriodicalId":72843,"journal":{"name":"Drug discovery today. Disease mechanisms","volume":"7 2","pages":"Pages e117-e122"},"PeriodicalIF":0.0000,"publicationDate":"2010-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ddmec.2010.07.005","citationCount":"26","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug discovery today. Disease mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1740676510000155","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 26
Abstract
Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is now recognized to play a central role in myocardial biology and disease. CaMKII appears to grade myocardial performance and regulate heart rate by catalyzing the phosphorylation of major proteins involved in cardiac excitation-contraction coupling. Under pathological stress, CaMKII activates hypertrophic and inflammatory transcriptional pathways and promotes apoptosis. Animal studies suggest that CaMKII inhibition may be an effective approach for treating common forms of structural heart disease.
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