Cell cycle regulation of the centrosome and cilium

Abstract

Centrosomes and cilia are conserved microtubule-based organelles whose structure and function depend on cell cycle stages. In dividing cells, centrosomes organize mitotic spindle poles, while in differentiating cells, centrosomes template ciliogenesis. Classically, this functional dichotomy has been attributed to regulation by cell cycle-dependent post-translational modifications, and recently PLK1, Nek2, Aurora A, and tubulin deacetylase were implicated in regulating the transition from cilia to centrosome. However, other recent studies suggest that tubulin dimers, the core structural components of centrosomes and cilia, also have a regulatory role. These regulatory mechanisms can be a target for chemotherapeutic intervention.