[Application of BODIPY-trimethylmelamine conjugate for DNA cross-linking in vitro].

Bioorganicheskaia khimiia Pub Date : 2011-03-01
V A Efimov, S V Fediunin, O G Chakhmakhcheva
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引用次数: 0

Abstract

Conjugate the fluorescent dye 4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indatsen-8-propionic acid (BODIPY) and N2,N4,N6-trimethylmelamine was obtained. It was shown that this compound in the presence of formaldehyde generates covalent cross-links of DNA strands in vitro.

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bodipy -三甲基三聚氰胺偶联物在体外DNA交联中的应用
将荧光染料4,4-二氟-1,3,5,7-四甲基-4-硼-3a,4 -二氮杂-s-茚三酮-8-丙酸(BODIPY)与N2,N4, n6 -三甲基三聚氰胺偶联。结果表明,在甲醛存在下,该化合物在体外产生DNA链的共价交联。
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