Curcumin-loaded into PLGA nanoparticles: preparation and in vitro schistosomicidal activity.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2012-02-01 Epub Date: 2011-07-08 DOI:10.1007/s00436-011-2527-9

Priscilla P Luz, Lizandra G Magalhães, Ana Carolina Pereira, Wilson R Cunha, Vanderlei Rodrigues, Marcio L Andrade E Silva

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引用次数: 34

Abstract

The incorporation of the curcumin into poly(lactic-co-glycolic)acid (PLGA) nanospheres by the nanoprecipitation technique, the characterization of the nanoparticles and the schistosomicidal activity of the curcumin-loaded into PLGA nanospheres were reported. The incorporation process occurred with high efficiency and the images of field-emission scanning electron microscopy (FESEM) revealed the production of spherically shaped particles. According to the dynamic light scattering measurements, the particles are nanometric and monodisperse. The curcumin-loaded PLGA nanoparticles (50 and 100 μM) caused the death of all worms and a separation between 50% and 100% of Schistosoma mansoni couples at concentrations from 30 μM. Moreover, the curcumin-loaded PLGA nanoparticles also decreased the motor activity and caused partial alterations in the tegument of adult worms. This study marks the first time that schistosomicidal activity has been reported for curcumin-loaded PLGA nanoparticles.

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姜黄素负载PLGA纳米颗粒的制备及其体外杀虫活性。

本文报道了用纳米沉淀法将姜黄素掺入聚乳酸-羟基乙酸(PLGA)纳米球，并对其进行了表征，同时对姜黄素掺入聚乳酸-羟基乙酸(PLGA)纳米球的杀虫活性进行了研究。混合过程效率高，场发射扫描电镜(FESEM)图像显示生成了球形颗粒。根据动态光散射测量，颗粒是纳米级和单分散的。载姜黄素的PLGA纳米颗粒(50 μM和100 μM)在30 μM以上的浓度下，线虫全部死亡，曼氏血吸虫偶分离率为50% ~ 100%。此外，载姜黄素的PLGA纳米颗粒也降低了成虫的运动活性，并引起成虫被皮的部分改变。本研究首次报道了载姜黄素的PLGA纳米颗粒的杀血吸虫活性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.