Exploiting the antioxidant potential of a common vitamin: Could vitamin C prevent postmenopausal osteoporosis?

IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Research Pub Date : 2011-08-10 DOI:10.1111/j.1447-0756.2011.01629.x
Vikram Sinai Talaulikar, Timothy Chambers, Isaac Manyonda
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引用次数: 14

Abstract

Aim:  Oxidative stress is thought to play a central role in the pathophysiology of various conditions affecting women's health, including cancer, preeclampsia and osteoporosis. On the back of animal experimentation, we sought to establish whether the oral administration of vitamin C at high doses to postmenopausal women would achieve the plasma antioxidant activity that could prevent osteoporosis.
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利用一种普通维生素的抗氧化潜能:维生素C能预防绝经后骨质疏松症吗?
目的:氧化应激被认为在影响女性健康的各种疾病的病理生理中起着核心作用,包括癌症、子痫前期和骨质疏松症。在动物实验的基础上,我们试图确定绝经后妇女口服高剂量维生素C是否能达到预防骨质疏松症的血浆抗氧化活性。方法:在我们的初步研究中,我们给8名健康的绝经后妇女服用10克维生素C,持续4周,并在基线和每周的基础上测量她们的血清维生素C和交叉交叉(骨转换的标志)水平。结果:我们发现血浆中维生素C水平最初有所上升,但在四周内迅速下降,尽管继续治疗,也无法维持,可能是由于吸收有限,甚至可能是由于排泄增加。结论:尽管维生素C具有抗氧化特性,但即使口服高剂量维生素C,也无法达到显示抗氧化活性所需的血清水平。这种方法不具有使用维生素C预防骨质疏松症的潜力,尽管其他给药途径可以克服这一点。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
376
审稿时长
3-6 weeks
期刊介绍: The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.
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