Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery

IF 7.9 2区 化学 Q1 CHEMISTRY, PHYSICAL Current Opinion in Colloid & Interface Science Pub Date : 2023-08-01 DOI:10.1016/j.cocis.2023.101705
Marité Cárdenas , Richard A. Campbell , Marianna Yanez Arteta , M. Jayne Lawrence , Federica Sebastiani
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引用次数: 2

Abstract

Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.

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核酸传递脂质纳米颗粒的结构设计综述
脂质纳米颗粒(LNPs)是最通用和最成功的基因传递系统,特别是在COVID-19疫苗中的应用。LNPs具有明确的核-壳结构,每个区域都有自己独特的组成,适合于广泛的体内递送应用。在这里,我们讨论了LNP结构的详细知识如何指导LNP的制定,以提高其核酸有效载荷的递送效率。详细介绍LNP结构设计如何指导更有效的核酸转染。概述了对此类开发所需的关键物理表征技术的看法,包括对生物物理方法的看法,这些方法既将生物流体中的结构与功能联系起来,又提高了它们逃离核内体和递送有效载荷的能力。
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来源期刊
CiteScore
16.50
自引率
1.10%
发文量
74
审稿时长
11.3 weeks
期刊介绍: Current Opinion in Colloid and Interface Science (COCIS) is an international journal that focuses on the molecular and nanoscopic aspects of colloidal systems and interfaces in various scientific and technological fields. These include materials science, biologically-relevant systems, energy and environmental technologies, and industrial applications. Unlike primary journals, COCIS primarily serves as a guide for researchers, helping them navigate through the vast landscape of recently published literature. It critically analyzes the state of the art, identifies bottlenecks and unsolved issues, and proposes future developments. Moreover, COCIS emphasizes certain areas and papers that are considered particularly interesting and significant by the Editors and Section Editors. Its goal is to provide valuable insights and updates to the research community in these specialized areas.
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