Enhancement or Suppression of ACE Inhibitory Activity by a Mixture of Tea and Foods for Specified Health Uses (FOSHU) That Are Marketed as "Support for Normal Blood Pressure".

ISRN Pharmaceutics Pub Date : 2011-01-01 Epub Date: 2011-08-04 DOI:10.5402/2011/712196

Isao Murakami, Hiroyuki Hosono, Shigeto Suzuki, Junichi Kurihara, Fumio Itagaki, Machiko Watanabe

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引用次数: 2

Abstract

The ACE inhibitory activities of mixtures of FOSHUs (Healthya, Goma-Mugicha, Lapis Support and Ameal) were examined in order to identify any antihypertensive interactions. Among combinations of Healthya with other samples that contain active peptides, only that with Ameal was found to have no inhibitory activity. Enhanced activity was observed in 2 other mixtures. The activity of a mixture of tea polyphenols and the whey component extracted from an Ameal solution was significantly decreased, thus demonstrating that whey protein lowered the ACE inhibitory activity of Healthya. Although oral administration of tea polyphenols alone significantly decreased SBP in SHR at 2 and 4 hr, combined administration with Ameal failed to decrease SBP at the same time points. In conclusion, the simultaneous intake of tea and FOSHUs that contain active peptides might affect daily self-antihypertensive management via enhancement or suppression of ACE inhibitory activity.

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以“支持正常血压”销售的茶和特定保健用途食品(FOSHU)的混合物增强或抑制ACE抑制活性

为了确定任何抗高血压的相互作用，我们检测了FOSHUs (Healthya, gama - mugicha, Lapis Support和Ameal)混合物的ACE抑制活性。在Healthya与其他含有活性肽的样品的组合中，只有与Ameal的组合被发现没有抑制活性。在另外两种混合物中观察到活性增强。茶多酚与乳清成分混合后的活性显著降低，表明乳清蛋白降低了Healthya的ACE抑制活性。虽然单独口服茶多酚可显著降低SHR患者在2小时和4小时的收缩压，但在同一时间点联合服用茶多酚未能降低收缩压。综上所述，同时摄入含有活性肽的茶和FOSHUs可能通过增强或抑制ACE抑制活性来影响日常自我降压管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ISRN Pharmaceutics

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