The effects of L-NAME on neuronal NOS and SOD1 expression in the DRG-spinal cord network of axotomised Thy 1.2 eGFP mice.

Neuron glia biology Pub Date : 2011-05-01 Epub Date: 2012-05-22 DOI:10.1017/S1740925X12000051

Matthew J G Bradman, Richard Morris, Anne McArdle, Malcolm J Jackson, Thimmasettappa Thippeswamy

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引用次数: 3

Abstract

Nitric oxide (NO) plays an important role in pathophysiology of the nervous system. Copper/zinc superoxide dismutase (SOD1) reacts with superoxide, which is also a substrate for NO, to provide antioxidative protection. NO production is greatly altered following nerve injury, therefore we hypothesised that SOD1 and NO may be involved in modulating axotomy responses in dorsal root ganglion (DRG)-spinal network. To investigate this interaction, adult Thy1.2 enhanced membrane-bound green fluorescent protein (eGFP) mice underwent sciatic nerve axotomy and received NG-nitro-

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L-NAME对Thy 1.2 eGFP小鼠腋窝切除后drg -脊髓网络神经元NOS和SOD1表达的影响。

一氧化氮(NO)在神经系统的病理生理中起着重要作用。铜/锌超氧化物歧化酶(SOD1)与超氧化物(NO的底物)发生反应，提供抗氧化保护。NO的产生在神经损伤后发生了很大的改变，因此我们假设SOD1和NO可能参与调节背根神经节(DRG)-脊髓网络的轴截反应。为了研究这种相互作用，成年Thy1.2增强的膜结合绿色荧光蛋白(eGFP)小鼠进行坐骨神经轴切开术并接受ng -硝基

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Neuron glia biology 医学-神经科学

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