Synthetic pressure sensitive adhesives for biomedical applications

IF 26 1区 化学 Q1 POLYMER SCIENCE Progress in Polymer Science Pub Date : 2023-07-01 DOI:10.1016/j.progpolymsci.2023.101692
Danielle M. Fitzgerald , Yolonda L. Colson , Mark W. Grinstaff
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引用次数: 4

Abstract

Pressure sensitive adhesives are components of everyday products found in homes, offices, and hospitals. Serving the general purpose of fissure repair and object fixation, pressure sensitive adhesives indiscriminately bind surfaces, as long as contact pressure is administered at application. With that being said, the chemical and material properties of the adhesive formulation define the strength of a pressure sensitive adhesive to a particular surface. Given our increased understanding of the viscoelastic material requirements as well as the intermolecular interactions at the binding interface required for functional adhesives, pressure sensitive adhesives are now being explored for greater use. New polymer formulations impart functionality and degradability for both internal and external applications. This review highlights the structure-property relationships between polymer architecture and pressure sensitive adhesion, specifically for medicine. We discuss the rational, molecular-level design of synthetic polymers for durable, removable, and biocompatible adhesion to wet surfaces like tissue. Finally, we examine prevalent challenges in biomedical wound closure and the new, innovative strategies being employed to address them. We conclude by summarizing the progress of current research, identifying additional clinical opportunities, and discussing future prospects.

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生物医学用合成压敏胶粘剂
压敏胶是家庭、办公室和医院日常用品的组成部分。适用于裂隙修复和物体固定的一般用途,只要在应用时施加接触压力,压敏粘接剂就可以不加选择地粘合表面。也就是说,粘合剂配方的化学和材料特性决定了压敏粘合剂对特定表面的强度。鉴于我们对粘弹性材料要求以及功能粘合剂所需的结合界面上的分子间相互作用的了解增加,压敏粘合剂现在正在探索更多的用途。新的聚合物配方赋予内部和外部应用的功能性和可降解性。本文综述了聚合物结构与压敏粘附之间的结构-性能关系,特别是用于医学。我们讨论了合理的,分子水平的合成聚合物的设计,持久,可移动,和生物相容性粘附在潮湿的表面,如组织。最后,我们研究了生物医学伤口愈合的普遍挑战和新的创新策略,以解决这些问题。最后,我们总结了目前的研究进展,确定了更多的临床机会,并讨论了未来的前景。
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来源期刊
Progress in Polymer Science
Progress in Polymer Science 化学-高分子科学
CiteScore
48.70
自引率
1.10%
发文量
54
审稿时长
38 days
期刊介绍: Progress in Polymer Science is a journal that publishes state-of-the-art overview articles in the field of polymer science and engineering. These articles are written by internationally recognized authorities in the discipline, making it a valuable resource for staying up-to-date with the latest developments in this rapidly growing field. The journal serves as a link between original articles, innovations published in patents, and the most current knowledge of technology. It covers a wide range of topics within the traditional fields of polymer science, including chemistry, physics, and engineering involving polymers. Additionally, it explores interdisciplinary developing fields such as functional and specialty polymers, biomaterials, polymers in drug delivery, polymers in electronic applications, composites, conducting polymers, liquid crystalline materials, and the interphases between polymers and ceramics. The journal also highlights new fabrication techniques that are making significant contributions to the field. The subject areas covered by Progress in Polymer Science include biomaterials, materials chemistry, organic chemistry, polymers and plastics, surfaces, coatings and films, and nanotechnology. The journal is indexed and abstracted in various databases, including Materials Science Citation Index, Chemical Abstracts, Engineering Index, Current Contents, FIZ Karlsruhe, Scopus, and INSPEC.
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