PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK.

Alfred Ayala, Yanli Ding, Rebecca J Rhee, Lesley A Doughty, Patrician S Grutkoski, Chun-Shiang Chung
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Abstract

Despite the recent advances in contemporary therapeutic, operative as well as supportive care sepsis and its associated co-morbidity/mortality are still a common occurrence in the critically ill trauma/surgical patient. Thus, it remains important to continue to expand our understanding of pathological components which drive the development of immune dysfunction contributing to subsequent multiple organ failure. Here we overview some of the immuno-pathological processes, cells and mediators which may play a role in the development of this immune dysfunctional condition.

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脓毒症和休克中抗炎/免疫抑制反应的病理方面。
尽管现代治疗、手术和支持性护理取得了最新进展,但败血症及其相关的并发症/死亡仍是创伤/手术重症患者的常见病。因此,继续扩大我们对病理因素的认识仍然非常重要,这些因素推动了免疫功能障碍的发展,并导致随后的多器官功能衰竭。在此,我们将概述一些可能在这种免疫功能失调的发展过程中发挥作用的免疫病理过程、细胞和介质。
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PATHOLOGICAL ASPECTS OF THE ANTI-INFLAMMATORY/IMMUNE SUPPRESSIVE RESPONSE IN SEPSIS AND SHOCK.
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