Analysis and Confirmation of 1,3-DMAA and 1,4-DMAA in Geranium Plants Using High Performance Liquid Chromatography with Tandem Mass Spectrometry at ng/g Concentrations.

Analytical Chemistry Insights Pub Date : 2012-01-01 Epub Date: 2012-11-08 DOI:10.4137/ACI.S10445
Heather L Fleming, Patricia L Ranaivo, Paul S Simone
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引用次数: 22

Abstract

1,3-Dimethylamylamine (1,3-DMAA) is a stimulant commercially sold in a variety of dietary supplements as a chemical species derived from geranium plants (Pelargonium graveolens). Whether 1,3-DMAA naturally occurs in geranium plants or other dietary ingredients, it has important regulatory and commercial ramifications. However, the analysis of 1,3-DMAA in geranium plants is not trivial due to low concentrations and a complex environmental matrix, requiring high selectivity and sensitivity. An extraction method combined with high performance liquid chromatography and tandem mass spectrometry is used to determine 1,3-DMAA and 1,4-dimethylamylamine (1,4-DMAA) concentrations in geranium plants with both external calibration and standard addition method. Samples from the Changzhou, Kunming, and Guiyang regions of China during both winter and summer were analyzed for 1,3-DMAA and 1,4-DMAA. The diastereomer ratios of the 1,3-DMAA stereoisomers of a racemic standard and the extracted plant were also quantified.

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用高效液相色谱-串联质谱法测定天竺葵植物中1,3- dmaa和1,4- dmaa的含量。
1,3-二甲氨基胺(1,3- dmaa)是一种从天竺葵植物(Pelargonium graveolens)中提取的化学物质,在各种膳食补充剂中出售。无论1,3- dmaa是否天然存在于天竺葵植物或其他膳食成分中,它都具有重要的监管和商业影响。然而,由于天竺葵植物中1,3- dmaa的浓度低,环境基质复杂,需要很高的选择性和灵敏度,因此分析工作并非易事。采用高效液相色谱-串联质谱联用提取法,采用外标法和标准加入法测定天竺葵植物中1,3- dmaa和1,4-二甲胺(1,4- dmaa)的浓度。对中国常州、昆明和贵阳地区冬季和夏季的样品进行了1,3- dmaa和1,4- dmaa的分析。测定了外消旋标准品和提取植物的1,3- dmaa立体异构体的非对映体比例。
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