Antimicrobial susceptibility pattern of extended spectrum beta-lactamase producing gram-negative bacteria isolated from wound and urine in a tertiary care hospital, Dhaka City, Bangladesh.
Refath Farzana, S M Shamsuzzaman, K Z Mamun, Paul Shears
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引用次数: 0
Abstract
From a total of 320 bacterial samples from wound swab and urine 169 (53%) gram-negative bacteria were isolated, of which 42 (25%) extended-spectrum beta-lactamase (ESBL) producers were detected by double-disk synergy test. ESBL producers were significantly more resistant against amoxiclav, Co-trimoxazole, ciprofloxacin, amikacin and gentamicin than non-ESBL producers. Among the 42 ESBL producers, 76% were positive for blaCTX-M and 43% were positive for blaOXA, with blaCTX-M predominantly (97%) observed in E. coli and blaOXA predominantly (80%) in Pseudomonas spp. Class 1 integron was found in 75% of blaCTX-M positive and 56% of blaOXA positive strains. Combinations of ESBL genes and class 1 integron were observed in 29 (69%) of the ESBL producers. The findings of this study infer that CTX-M and OXA producers are emerging in Bangladesh and we report the presence of blaOXA for the first time in Bangladesh.
期刊介绍：
The SEAMEO* Regional Tropical Medicine and Public Health Project was established in 1967 to help improve the health and standard of living of the peoples of Southeast Asia by pooling manpower resources of the participating SEAMEO member countries in a cooperative endeavor to develop and upgrade the research and training capabilities of the existing facilities in these countries. By promoting effective regional cooperation among the participating national centers, it is hoped to minimize waste in duplication of programs and activities. In 1992 the Project was renamed the SEAMEO Regional Tropical Medicine and Public Health Network.
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