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Knowledge and Practice of Basic Life Support among Health Workers in the Upper Denkyira East Municipality of Ghana 加纳东登基拉上市卫生工作者的基本生命支持知识和实践
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-14 DOI: 10.9734/ajmah/2023/v21i11944
Philip Gyaase, Emmanuel Boateng Acheampong, Isaiah Adu-Gyamfi, Bridget Armah, Gifty Delali Amewolah, Emmanuel Owusu Adueming
Background: The medical procedure known as cardiopulmonary resuscitation (CPR) can save a person's life after a heart attack. Additionally, it is done to manually preserve full brain function while additional measures are taken to recover spontaneous breathing and normal unprompted blood circulation in cardiac arrest. Methods: The study's goal was to assess the knowledge and practice of basic life support among health workers in the Upper Denkyira East Municipality, Central Region of Ghana. The study used cross-sectional design. The study respondents were chosen using a simple random sampling method which included 322 nurses, doctors, physician assistants and midwives working in the Municipality. Data were collected using a standardized questionnaire. Data were analysed with SPSS version 25 and summarized using frequencies and percentages. Pearson's chi-square test and multivariate logistic regression were used to examine associations at a 5% significance level. Results: The study found that while all health care workers had heard about BLS, they only had an average of 68.9 percent understanding of basic life support and just 16.5 percent had practiced CPR before. Also, there was significant association between sociodemographic characteristics (sex, grade, educational level, department and work experience) of the health workers and the practice of basic life support (p-value=<0.001). Conclusion: The study concludes that if health workers are given more training and support, the knowledge and practice of basic life support would be increased in the Upper Denkyira East Municipality.
背景:被称为心肺复苏术(CPR)的医疗程序可以在心脏病发作后挽救人的生命。此外,在采取额外措施恢复心脏骤停时的自主呼吸和正常的非促性血液循环的同时,还可以手工保持完整的脑功能。 方法:本研究的目的是评估加纳中部地区上登基拉东部市卫生工作者的基本生命支持知识和实践情况。本研究采用横断面设计。调查对象采用简单随机抽样的方法,包括322名在本市工作的护士、医生、医师助理和助产士。使用标准化问卷收集数据。数据采用SPSS版本25进行分析,并采用频率和百分比进行汇总。使用Pearson卡方检验和多变量逻辑回归在5%显著性水平下检验相关性。结果:研究发现,虽然所有的卫生保健工作者都听说过BLS,但他们平均只有68.9%的人了解基本生命支持,只有16.5%的人以前练习过心肺复苏术。此外,卫生工作者的社会人口学特征(性别、年级、教育程度、科室和工作经验)与基本生命支持实践之间存在显著关联(p值=<0.001)。结论:研究得出的结论是,如果向卫生工作者提供更多的培训和支持,上登基拉东市的基本生命支持知识和实践将会增加。
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引用次数: 0
An Overview of Drug Abuse: Causes, Effects, and Control Measures 药物滥用概述:原因、影响和控制措施
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-14 DOI: 10.9734/ajmah/2023/v21i11945
M. L. John, I. J. J. Otene, G. E. Antenyi
This study was conducted to assess the causes, effects, and control measures of drug abuse. The review was composed of literature search from databases (Google Scholar, Science Direct, Springer, Scopus and PubMed). Major findings from this study includes: a) Causes of Drug Abuse: The causes of drug abuse varies from social, interpersonal, cultural, environmental, and family factors. People abuse drugs due to pleasure derived from it. Drug abuse can be socially learned through drug use by peer group members, exposure to offers to use, and easy access to drugs. Pressure from friends that abuse drugs including their frequent escalation of drug experience may appeal others to start the use of drugs. Curiosity arising from recurrent references to drugs by public media generate curiosity for having a personal experience of the drugs. Growing up in a single-parent family, lack of parental support or supervision as well as low involvement with the child, and exposure of children to elders in the family who take drugs can promote drug use. Frustration and depression could make some people to take drugs to experience relief or relief from pain mostly from a prolonged use of pain-relieving drugs prescribed by a doctor. b) Effects of Drug Abuse: The signs or harmful effects of drug abuse could be physical, emotional, family dynamics, school behaviours, and social problems. They include cardiovascular disease; abnormalities in brain structure and function; respiratory problems; weakened immune system; insomnia; reduction in libido or sexual dysfunction; anxiety and irritability; loss or increase in appetite; and poor judgment. Different crimes such as armed robbery, kidnapping, and rape have been identified with young people under the influence of drugs. Family dynamics will reflect in the form of secretiveness, withdrawing from family, starting arguments, and breaking rules. For the school behaviours, the teenager will begin to play truancy, display discipline problems, decline in grades, decreased interest, many absences, and subsequently withdrawal from school. In terms of social problems, the teenager will begin to have problems with the law, have new friends, abnormal request for money, changes to less conventional styles in dress and music. c) Control Measures for Drug Abuse: Effective drug prevention programs should involve the family, schools, communities, and the media. This includes creating healthy home environment (functional family communication or interaction, parents taking extra measures to monitor the activities of their children including their associations, reduce child’s exposure to drug users in the family). Government should provide easy and affordable access to rehabilitation centres, implement effective addiction counselling and prevention programmes, provide policies that would address the wider availability of drugs in the society, create job opportunities for youth to become self-reliant; develop effective a
本研究旨在评估药物滥用的原因、影响及控制措施。本综述由文献检索数据库(谷歌Scholar、Science Direct、施普林格、Scopus和PubMed)组成。本研究的主要发现包括: & # x0D;a)药物滥用的原因:药物滥用的原因因社会、人际、文化、环境和家庭因素而异。人们滥用毒品是为了从中获得快感。药物滥用可以通过同辈群体成员吸毒、接触到吸毒机会以及容易获得毒品而在社会上习得。来自朋友滥用毒品的压力,包括他们吸毒经验的频繁升级,可能会吸引其他人开始使用毒品。公众媒体反复提及毒品所引起的好奇心,也促使人们产生了亲身体验毒品的好奇心。在单亲家庭中长大,缺乏父母的支持或监督,与孩子的接触较少,以及孩子接触吸毒的家庭长辈,都可能促进吸毒。沮丧和抑郁可能会使一些人通过服用药物来缓解或减轻疼痛,主要是通过长期服用医生开的止痛药来缓解疼痛。 b)药物滥用的影响:药物滥用的迹象或有害影响可能是身体、情感、家庭动态、学校行为和社会问题。它们包括心血管疾病;大脑结构和功能异常;呼吸系统疾病;免疫系统减弱;失眠;性欲减退或性功能障碍;焦虑和易怒;食欲不振:食欲不振或增加;判断力差。持械抢劫、绑架和强奸等不同的犯罪行为都被认定与毒品影响下的年轻人有关。家庭动态将反映在秘密的形式,退出家庭,开始争论,打破规则。对于学校行为,青少年会开始逃学,表现出纪律问题,成绩下降,兴趣下降,经常缺勤,随后退学。在社会问题方面,青少年将开始有法律问题,有新的朋友,不正常的要求钱,改变不那么传统的风格在服装和音乐。 c)药物滥用的控制措施:有效的药物预防计划应该包括家庭、学校、社区和媒体。这包括创造健康的家庭环境(有效的家庭沟通或互动,父母采取额外措施监测其子女的活动,包括他们的交往,减少儿童接触家庭中的吸毒者)。政府应提供方便和负担得起的康复中心,执行有效的成瘾咨询和预防方案,提供政策解决社会上更广泛的毒品供应问题,为青年创造就业机会,使他们能够自力更生;制定有效的药物滥用意识/宣传方案;建立康乐中心;最后,宗教信仰可以防止人们使用毒品,即使他们暴露在毒品的环境中。
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引用次数: 0
Knowledge and Practice of Basic Life Support among Health Workers in the Upper Denkyira East Municipality of Ghana 加纳东登基拉上市卫生工作者的基本生命支持知识和实践
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-14 DOI: 10.9734/ajmah/2023/v21i11943
Philip Gyaase, Emmanuel Boateng Acheampong, Isaiah Adu-Gyamfi, Bridget Armah, Gifty Delali Amewolah, Emmanuel Owusu Adueming
Background: The medical procedure known as cardiopulmonary resuscitation (CPR) can save a person's life after a heart attack. Additionally, it is done to manually preserve full brain function while additional measures are taken to recover spontaneous breathing and normal unprompted blood circulation in cardiac arrest. Methods: The study's goal was to assess the knowledge and practice of basic life support among health workers in the Upper Denkyira East Municipality, Central Region of Ghana. The study used cross-sectional design. The study respondents were chosen using a simple random sampling method which included 322 nurses, doctors, physician assistants and midwives working in the Municipality. Data were collected using a standardized questionnaire. Data were analysed with SPSS version 25 and summarized using frequencies and percentages. Pearson's chi-square test and multivariate logistic regression were used to examine associations at a 5% significance level. Results: The study found that while all health care workers had heard about BLS, they only had an average of 68.9 percent understanding of basic life support and just 16.5 percent had practiced CPR before. Also, there was significant association between sociodemographic characteristics (sex, grade, educational level, department and work experience) of the health workers and the practice of basic life support (p-value=<0.001). Conclusion: The study concludes that if health workers are given more training and support, the knowledge and practice of basic life support would be increased in the Upper Denkyira East Municipality.
背景:被称为心肺复苏术(CPR)的医疗程序可以在心脏病发作后挽救人的生命。此外,在采取额外措施恢复心脏骤停时的自主呼吸和正常的非促性血液循环的同时,还可以手工保持完整的脑功能。 方法:本研究的目的是评估加纳中部地区上登基拉东部市卫生工作者的基本生命支持知识和实践情况。本研究采用横断面设计。调查对象采用简单随机抽样的方法,包括322名在本市工作的护士、医生、医师助理和助产士。使用标准化问卷收集数据。数据采用SPSS版本25进行分析,并采用频率和百分比进行汇总。使用Pearson卡方检验和多变量逻辑回归在5%显著性水平下检验相关性。结果:研究发现,虽然所有的卫生保健工作者都听说过BLS,但他们平均只有68.9%的人了解基本生命支持,只有16.5%的人以前练习过心肺复苏术。此外,卫生工作者的社会人口学特征(性别、年级、教育程度、科室和工作经验)与基本生命支持实践之间存在显著关联(p值=<0.001)。结论:研究得出的结论是,如果向卫生工作者提供更多的培训和支持,上登基拉东市的基本生命支持知识和实践将会增加。
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引用次数: 0
Adverse Reaction to Ceftriaxone: How Far Can We Go to exclude an Allergy? 头孢曲松不良反应:我们能在多大程度上排除过敏?
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-11 DOI: 10.9734/ajmah/2023/v21i11942
Benchidmi Sara, Aminou Sara, Jaabouti Ghizlan, Benchekroun Soumia, EL Hafidi Naima, Mahraoui Chafiq
In the pediatric population, cephalosporins are one of the most often prescribed antibiotic groups. Currently, the European Network for Drug Allergy's (ENDA) standardized diagnostic techniques are widely used to diagnose beta lactam allergic reactions, which help physicians to confirm or exclude the allergy. Here, we report a case of an incorrectly labeled child of allergy to ceftriaxone after presenting a reaction minutes after the administration of the first dose of ceftriaxone. The allergic pathogenesis was suspected based on the clinical data (brief interval between the drug injection and the appearance of symptoms). we performed skin tests, intradermal tests (IDT) for ceftriaxone, which turn out negatives, then we found an alternative drug for the patient to use by testing ceftazidime and amoxicillin and finally, since the symptoms weren’t specific of an allergy reaction and more likely suggesting a vasovagal syncope, we pursued with an intravenous drug provocation test to ceftriaxone, those tests helped us to prove the innocence of ceftriaxone and enabled us to reassure the parents. Doctors should be mindful of the risks associated with avoiding specific antibiotic classes, particularly beta lactams, which are the most frequently recommended first-line antibiotics for pediatric patients and whose exclusion may complicate the management of certain pathologies. Such an approach may increase the number of infections, have an influence on antimicrobial stewardship, and have negative health economic effects on the public, it is crucial to avoid identifying a child as allergic without first performing an appropriate diagnostic workup.
在儿科人群中,头孢菌素是最常用的抗生素组之一。目前,欧洲药物过敏网络(ENDA)的标准化诊断技术被广泛用于诊断β -内酰胺过敏反应,帮助医生确认或排除过敏。在这里,我们报告了一例错误标记的儿童对头孢曲松过敏后提出的反应几分钟后,头孢曲松第一剂的管理。根据临床资料(注射药物与出现症状的时间间隔较短),怀疑过敏发病机制。我们对头孢曲松进行了皮肤测试,皮内测试(IDT),结果都是阴性的,然后我们通过测试头孢他啶和阿莫西林为患者找到了一种替代药物,最后,由于症状不是过敏反应的特异性,更可能是血管迷走神经性晕厥,我们对头孢曲松进行了静脉药物激发试验,这些试验帮助我们证明了头孢曲松是无害的,使我们能够让父母放心。医生应注意避免使用特定种类抗生素的风险,尤其是内酰胺类抗生素,这是儿科患者最常推荐的一线抗生素,排除内酰胺类抗生素可能会使某些疾病的治疗复杂化。这种方法可能会增加感染数量,对抗菌剂管理产生影响,并对公众产生负面的健康经济影响。因此,在没有首先进行适当的诊断检查之前,避免将儿童确定为过敏是至关重要的。
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引用次数: 0
Ultrasonography as a Tool in Assessment of Breast Pain among Women 超声检查作为评估女性乳房疼痛的工具
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-09 DOI: 10.9734/ajmah/2023/v21i11941
Hadijat Oluseyi Kolade-Yunusa
Background: Breast pain or mastalgia is a common breast symptom in women after breast lump. The increase in awareness of breast cancer and the possibility that a breast pain may be associated with underlying breast disease prompt women to seek medical attention. Ultrasound is a valuable imaging modality in evaluation of breast pain and breast diseases in general. Objectives: To determine the role of ultrasound and the outcome of breast ultrasound among women with breast pain. Methods: This cross-sectional descriptive study was conducted on 87 women who were referred for ultrasound scan on account of breast pain from July 2015 - December 2016 at radiology department of UATH. A high frequency linear transducer 7.5 MHz of EMP G70 ultrasound machine manufactured by Shenzhen Emperor Electronic Technology®, China 2011 was used in scanning the breast. Results: The mean age of study population was 32±15years with age range of 16 and 69 years. Majority of the patients were in the age group 30-39 years representing 54.0%. 32(36.8%) of women with breast pain had abnormal ultrasound findings. Sonographic findings included mass 13 (14.9%), cyst 10 (11.5%), ductal dilation 4(4.6%), calcification 3(3.5%), architectural distortion 2(2.3%). BIRADS 1 (normal/negative) was the commonest category seen in 55(63.2%) of patients, 21(24.1%) were benign (BIRADS 2), 6(6.4%) were probably benign (BIRADS 3), 3(3.4%) were suspicious BIRADS 4 and 2(2.3%) were highly suggestive of malignancy BIRADS 5. There was positive correlation between ultrasound findings with age This was however not statistically significant (P=0.67). There was positive correlation between abnormal ultrasound findings with type of pain (P=0.08), location of pain (P=0.63), contraception (P=0.39), and family history of breast cancer (P=0.11). However, this was not statistically significant Conclusion: Evaluation of breast pain in a woman is very essentially not only to alleviate her fears but also to detect any abnormalities which may require treatment medically or surgically. Ultrasound is an important imaging tool in evaluating women with breast pain.
背景:乳房疼痛或乳房痛是乳房肿块后女性常见的乳房症状。对乳腺癌认识的提高以及乳房疼痛可能与潜在的乳房疾病有关的可能性促使妇女寻求医疗照顾。超声是评估乳房疼痛和乳腺疾病的一种有价值的成像方式。 目的:探讨超声在乳房疼痛患者中的作用及预后。 方法:对2015年7月至2016年12月在南京中医药大学放射科因乳房疼痛转诊行超声扫描的87例女性患者进行横断面描述性研究。乳房扫描采用中国深圳英皇电子科技公司2011年生产的EMP G70超声机7.5 MHz高频线性换能器。 结果:研究人群平均年龄32±15岁,年龄范围16 ~ 69岁。大多数患者年龄在30-39岁,占54.0%。32例(36.8%)乳房疼痛患者超声表现异常。超声表现包括肿块13例(14.9%),囊肿10例(11.5%),导管扩张4例(4.6%),钙化3例(3.5%),建筑变形2例(2.3%)。BIRADS 1(正常/阴性)是55例(63.2%)患者中最常见的类型,21例(24.1%)为良性(BIRADS 2), 6例(6.4%)为可能良性(BIRADS 3), 3例(3.4%)为可疑(BIRADS 4), 2例(2.3%)为高度提示恶性(BIRADS 5)。超声结果与年龄呈正相关,但无统计学意义(P=0.67)。超声异常表现与疼痛类型(P=0.08)、疼痛部位(P=0.63)、避孕措施(P=0.39)、乳腺癌家族史(P=0.11)呈正相关。然而,这在统计学上并不显著 结论:对女性乳房疼痛的评估不仅要减轻她的恐惧,而且要发现任何可能需要药物或手术治疗的异常情况。超声是评估女性乳房疼痛的重要影像学工具。
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引用次数: 0
Complicated Appendicitis-An Update : A Narrative Review 复杂阑尾炎:最新述评
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-08 DOI: 10.9734/ajmah/2023/v21i11940
None Kumar H, R., None Soma M., None Saw M. O.
Complicated Appendicitis is defined as perforated appendicitis with abscess or mass formation. Its diagnosis and management have been controversial with no consensus on its definition and treatment algorithm. The treatment was initially conservative management, but the current trend is immediate appendectomy by the laparoscopic method. Other areas of controversy include the need for interval appendectomy and the role of percutaneous drainage of appendicular abscess. We have conducted this review article to investigate the definition, diagnosis, and treatment of complicated appendicitis.
复杂性阑尾炎定义为阑尾炎穿孔伴脓肿或肿块形成。其诊断和治疗一直存在争议,对其定义和治疗方法尚无共识。治疗最初是保守管理,但目前的趋势是通过腹腔镜方法立即阑尾切除术。其他有争议的领域包括是否需要间隔阑尾切除术和经皮引流阑尾脓肿的作用。我们就复杂性阑尾炎的定义、诊断和治疗进行综述。
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引用次数: 0
The Impact of Upper Limb Functioning on Gait Patterns in Individuals with Post-Stroke Hemiplegia 上肢功能对卒中后偏瘫患者步态模式的影响
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-07 DOI: 10.9734/ajmah/2023/v21i11939
G. D. S. Pushpika, T. N. Samaranayake
Hemiplegia resulting from a stroke leads to a distinct gait pattern and dysfunction in the upper limb. The objective of this study was to determine a correlation between the functionality of the upper limb and selected spatiotemporal parameters of gait in patients with hemiplegia following a stroke. The study comprised a sample of 80 outpatients (45 males and 35 females) with post-stroke hemiplegia, with an average age of 60.78 years, selected using a convenient sampling method. To assess the functionality of the affected upper limb, the study employed the QuickDASH questionnaire, which is a shortened version of the Disabilities of the Arm, Shoulder, and Hand questionnaire. Concurrently, the participants were recorded on video while performing the 4-meter walk test (4mWT). The recorded videos were meticulously analyzed using Kinovea software (version 0.8.15) to calculate gait parameters such as comfortable and maximum speeds, stride length and time on the paretic and affected side, number of steps taken to cover the 4m, and cadence. Pearson Correlation analysis was conducted to explore potential associations between these gait parameters and the QuickDASH score, with a significance level of p < 0.05. The findings revealed significant correlations between upper limb functionality and selected gait parameters. Reduced upper limb functionality correlated with decreased comfortable speed (p < 0.05), maximum speed (p < 0.05), and cadence (p < 0.05) during the 4mWT. In contrast, impaired upper limb function linked to prolonged time to complete the 4m distance (p < 0.05), increased steps taken by both affected (p < 0.05) and unaffected (p < 0.05) sides, and extended stride time on both sides (p < 0.05). However, no substantial correlation emerged between upper limb functionality and stride length on either side (p > 0.05). In conclusion, this study emphasizes the correlation between upper limb functionality and specific gait parameters in post-stroke hemiplegic patients. The correlation between upper limb functionality and selected spatiotemporal parameters of gait underscores the necessity for integrated rehabilitation strategies targeting both upper limb and gait training. These findings contribute to a deeper comprehension of the connection between upper limb disability and gait parameters, emphasizing the significance of personalized treatments in order to maximize the restoration of functionality in individuals who have suffered a stroke.
中风引起的偏瘫会导致明显的步态模式和上肢功能障碍。本研究的目的是确定中风后偏瘫患者上肢功能与步态的时空参数之间的相关性。本研究采用方便抽样法选取80例中风后偏瘫门诊患者,其中男性45例,女性35例,平均年龄60.78岁。为了评估受影响的上肢的功能,研究采用了QuickDASH问卷,这是手臂,肩膀和手的残疾问卷的简化版本。同时,参与者在进行4米步行测试(4mWT)时进行视频记录。使用Kinovea软件(版本0.8.15)对录制的视频进行仔细分析,计算步态参数,如舒适和最大速度,步幅长度和在麻痹和患病侧的时间,走完4米的步数以及节奏。进行Pearson相关分析,探讨这些步态参数与QuickDASH评分之间的潜在关联,显著性水平为p <0.05 # x0D公司;研究结果显示上肢功能与选定的步态参数之间存在显著相关性。上肢功能降低与舒适速度降低相关(p <0.05),最大速度(p <0.05),节奏(p <0.05)。相比之下,上肢功能受损与完成4米距离的时间延长有关(p <0.05),受影响双方采取的步骤增加(p <0.05)和未受影响(p <(p <0.05)。然而,上肢功能与两侧步幅之间没有明显的相关性(p >0.05)强生# x0D;总之,本研究强调脑卒中后偏瘫患者上肢功能与特定步态参数的相关性。上肢功能与选定的步态时空参数之间的相关性强调了针对上肢和步态训练的综合康复策略的必要性。这些发现有助于更深入地理解上肢残疾和步态参数之间的联系,强调个性化治疗的重要性,以最大限度地恢复中风患者的功能。
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引用次数: 0
The Prevalence of Microalbuinuria & Associated Risk Factors at the Time of Diagnosis among Type 2 Diabetic Patients in Rajshahi City, Bangladesh 微量白蛋白尿的流行病学研究孟加拉国拉杰沙希市2型糖尿病患者诊断时的相关危险因素
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-11-06 DOI: 10.9734/ajmah/2023/v21i11938
Rumana Ferdous, Md. Mamunur Rahman, Chaman Ara, Md. Hasan Al Khurshid, Humayra Rumu
Background: The presence of albumin in the urine is a marker of glomerular involvement in type 2 diabetes mellitus (T2DM), depicting diabetic nephropathy. Strict glycemic control can prevent and delay the occurrence of microalbuminuria and other diabetic complications. Therefore, this study evaluated the prevalence of microalbuinuria & associated risk factors at the timi e of diagnosis among type 2 diabetic patients in Rajshahi city. Methods: Between January 2019 and December 2019, a cross-sectional analytical study was collaboratively undertaken by the Department of Physiology at Rajshahi Medical College and the Diabetic Association Hospital in Rajshahi. Following an initial evaluation, patients underwent an oral glucose tolerance test (OGTT) for a conclusive diagnosis of DM. Subsequently, subjects were subjected to rigorous screening procedures based on specific inclusion and exclusion criteria. Study group A consisted of 80 diabetic subjects, while an equivalent number of age- and gender-matched non-diabetic individuals were recruited for study group B, with participants drawn from hospital staff, patients' relatives, and volunteers, resulting in a total of 80 participants in each group. Results: The study findings showed that among the healthy adult group, 85% had normal fasting blood sugar (FBS), while 15% had impaired fasting sugar (IFG). Conversely, in the diabetic group, none had normal FBS or IFG. The mean urine microalbumin level was significantly higher in the diabetic group (24.63±14.75 mg/day) compared to the control group (11.59±5.41 mg/day), indicating abnormal levels in about one-third of diabetic respondents versus none in the healthy group. Additionally, all healthy adults had normal urine spot microalbumin levels, whereas 25 diabetic respondents exceeded normal levels. Conclusion: Newly diagnosed diabetic patients showed higher levels of urine microalbumin compared to healthy adults, suggesting potential early markers for diabetic nephropathy. However, further large-scale prospective studies are required to confirm their clinical usefulness for routine screening.
背景:尿中白蛋白的存在是2型糖尿病(T2DM)肾小球受累的标志,是糖尿病肾病的表征。严格控制血糖可以预防和延缓微量白蛋白尿等糖尿病并发症的发生。因此,本研究评估了微量白蛋白尿的患病率。Rajshahi市2型糖尿病患者诊断时的相关危险因素分析。 方法:2019年1月至2019年12月,由拉杰沙希医学院生理学系和拉杰沙希糖尿病协会医院合作开展了一项横断面分析研究。在初步评估后,患者接受口服葡萄糖耐量试验(OGTT)以确诊糖尿病。随后,受试者根据特定的纳入和排除标准进行严格的筛选程序。研究小组A包括80名糖尿病患者,而研究小组B招募了同等数量的年龄和性别匹配的非糖尿病患者,参与者来自医院工作人员,患者亲属和志愿者,每组总共有80名参与者。结果:研究结果显示,在健康成人中,85%的人空腹血糖(FBS)正常,15%的人空腹血糖(IFG)受损。相反,在糖尿病组中,没有人有正常的FBS或IFG。糖尿病组尿微量白蛋白的平均水平(24.63±14.75 mg/天)明显高于对照组(11.59±5.41 mg/天),这表明大约三分之一的糖尿病应答者尿微量白蛋白水平异常,而健康组没有。此外,所有健康成人的尿斑微量白蛋白水平正常,而25名糖尿病患者的尿斑微量白蛋白水平超过正常水平。 结论:新诊断的糖尿病患者尿微量白蛋白水平高于健康成人,提示糖尿病肾病的潜在早期标志物。然而,需要进一步的大规模前瞻性研究来证实它们在常规筛查中的临床应用。
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引用次数: 0
Factors Predisposing to Postdural Puncture Headache after Spinal Anaesthesia among Elective Caesarean Section Patients at Thika Level 5 Hospital, Kenya 肯尼亚Thika 5级医院择期剖宫产患者脊髓麻醉后硬脊膜穿刺头痛的易感因素
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-10-31 DOI: 10.9734/ajmah/2023/v21i11937
Munavu Angelina Nduku, Onyuka Jackson, Mwangi Wambui
Background: Postdural puncture headache (PDPH) is a common complication following spinal anaesthesia for Caesarean section (CS). There is little data on the incidence and its predisposing factors in low-income countries. The study aimed to investigate the incidence and factors predisposing patients to PDPH after a dural puncture during a planned Caesarean section under spinal anaesthesia at Thika Level 5 Hospital, Kenya. Methods: A cross-sectional study design was used. Pregnant women scheduled for planned Caesarean sections under spinal anaesthesia at Thika Level 5 Hospital were randomly recruited. Data was collected during the fourth quarter of 2021. Patient factors (age, BMI, bed rest, and previous history of PDPH), healthcare provider factors (qualification, experience, and the number of dural punctures), and equipment factors (size, design, and spinal needle orientation) were evaluated to determine predisposing factors for PDPH. Sample size obtained by the use of Fisher’s formula, resulting in a sample size of 103. Results: We found the incidence of PDPH at Thika Level 5 Hospital to be 24.5%. Patient and equipment factors were found to be associated with PDPH. Among the patient factors, high BMI was found to be significant (p = 0.039) while among the equipment factors, traumatic needle tip design (p = 0.049) and the perpendicular orientation of needle bevel (p = 0.022) were found to be associated with PDPH. Conclusion and Recommendations: We conclude that PDPH is a common complication following spinal anaesthesia for Caesarean section, and the incidence (24.5%) is relatively high at Thika Level 5 Hospital. High BMI, traumatic cutting spinal needle tip design and perpendicular orientation of the needle bevel are predisposing factors. Further research is needed to determine the predisposing factors of PDPH at different levels of hospitals in Kiambu County, and understand the specific mechanisms and measures to minimize the incidence PDPH
背景:硬脊膜穿刺后头痛(PDPH)是剖宫产(CS)脊髓麻醉后常见的并发症。关于低收入国家发病率及其诱发因素的数据很少。该研究旨在调查肯尼亚Thika 5级医院脊髓麻醉下计划剖宫产术中硬脑膜穿刺后PDPH的发生率和易感因素。方法:采用横断面研究设计。在Thika 5级医院随机招募计划在脊髓麻醉下进行剖腹产的孕妇。数据收集于2021年第四季度。评估患者因素(年龄、BMI、卧床休息和既往PDPH史)、医疗保健提供者因素(资格、经验和硬脑膜穿刺次数)和设备因素(尺寸、设计和脊髓针朝向),以确定PDPH的易感因素。利用费雪公式得到的样本量,得到的样本量为103。 结果:在西卡5级医院,PDPH的发生率为24.5%。患者和设备因素被发现与PDPH有关。在患者因素中,高BMI具有显著性(p = 0.039),而在器械因素中,创伤性针尖设计(p = 0.049)和针尖垂直方向(p = 0.022)与PDPH相关。 结论与建议:PDPH是剖宫产脊髓麻醉后常见的并发症,在Thika 5级医院发生率较高(24.5%)。高BMI,创伤性脊髓针尖设计和针尖斜面垂直方向是诱发因素。需要进一步研究确定基安布县各级医院PDPH的易感因素,了解降低PDPH发生率的具体机制和措施
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引用次数: 0
Idiopathic Pulmonary Hemosiderosis in Pediatric in Patients: Report of Four Cases in Rabat, Morrocco 小儿特发性肺含铁血黄素病:摩洛哥拉巴特4例报告
4区 医学 Q4 INFECTIOUS DISEASES Pub Date : 2023-10-30 DOI: 10.9734/ajmah/2023/v21i11935
None Benchidmi S., None Lamghari Y., None Saad A., None Maalmi N., None Jaabouti G., None Aminou S., None Elqoraichi O., None EL Hafidi N., None Mahraoui C., None Benchekroun S.
Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage. Patients with IPH usually present with the classical triad: hemoptysis, and iron deficiency anemia, and pulmonary infiltrates on chest imaging, the diagnosis is often delayed by years. We report four IPH pediatrics cases of children diagnosed at the children’s hospital of Rabat, Morocco. The aim of this study is to review the clinical manifestations, diagnostic tools and treatment of this affection. All the four patients were presented with the classical triad, the diagnosis was based on the Clinical, radiologic and biologic findings. Bronchoalveolar lavage was performed to all the patients and confirmed the diagnosis by the identification of siderophages. High doses of Corticosteroids, by an induction therapy with an intravenous methylprednisolone (20 mg/kg/day for 3 days) followed by oral prednisone (1 mg/kg/day) had shown a good therapeutic response. One patient was treated first with oral corticosteroid and switched over to synthetic antimalarial drugs, because he had side effects from long-term cortico therapy. Then the clinical condition has been improved. The evaluation of response to the therapy included the clinical symptoms and signs, laboratory data and chest x ray. The prognosis of IPH is influenced by several factors, including the time of diagnosis, early initiation of treatment, and the presence of comorbidities.
摘要特发性肺含铁血黄素沉着症是一种罕见的肺泡弥漫性出血的病因。IPH患者通常表现为典型的三联征:咯血、缺铁性贫血,胸部影像学表现为肺部浸润,诊断往往延迟数年。我们报告了在摩洛哥拉巴特儿童医院诊断的四例IPH儿科儿童病例。本研究的目的是回顾该疾病的临床表现、诊断工具和治疗方法。 所有4例患者均表现为典型的三联征,诊断依据临床、放射学和生物学检查结果。所有患者均行支气管肺泡灌洗,并通过鉴定嗜侧噬细胞确认诊断。 高剂量皮质类固醇,通过静脉注射甲基强的松龙(20mg /kg/天,连续3天)诱导治疗,然后口服强的松(1mg /kg/天)显示出良好的治疗反应。一名患者首先接受口服皮质类固醇治疗,然后改用合成抗疟疾药物,因为他长期服用皮质类固醇治疗有副作用。临床情况得到改善。对治疗效果的评价包括临床症状和体征、实验室资料和胸部x线片。IPH的预后受几个因素的影响,包括诊断时间、早期开始治疗和合并症的存在。
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引用次数: 0
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Southeast Asian Journal of Tropical Medicine and Public Health
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