Increased Cortical Thickness in Male-to-Female Transsexualism.

Eileen Luders, Francisco J Sánchez, Duygu Tosun, David W Shattuck, Christian Gaser, Eric Vilain, Arthur W Toga
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引用次数: 67

Abstract

Background: The degree to which one identifies as male or female has a profound impact on one's life. Yet, there is a limited understanding of what contributes to this important characteristic termed gender identity. In order to reveal factors influencing gender identity, studies have focused on people who report strong feelings of being the opposite sex, such as male-to-female (MTF) transsexuals.

Method: To investigate potential neuroanatomical variations associated with transsexualism, we compared the regional thickness of the cerebral cortex between 24 MTF transsexuals who had not yet been treated with cross-sex hormones and 24 age-matched control males.

Results: Results revealed thicker cortices in MTF transsexuals, both within regions of the left hemisphere (i.e., frontal and orbito-frontal cortex, central sulcus, perisylvian regions, paracentral gyrus) and right hemisphere (i.e., pre-/post-central gyrus, parietal cortex, temporal cortex, precuneus, fusiform, lingual, and orbito-frontal gyrus).

Conclusion: These findings provide further evidence that brain anatomy is associated with gender identity, where measures in MTF transsexuals appear to be shifted away from gender-congruent men.

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男性变女性的大脑皮层厚度增加。
背景:一个人认为自己是男性还是女性的程度对他的一生有着深远的影响。然而,对于是什么促成了这个被称为性别认同的重要特征,人们的理解是有限的。为了揭示影响性别认同的因素,研究集中在那些有强烈异性感觉的人身上,比如男变女(MTF)变性者。方法:为了研究与变性欲症相关的潜在神经解剖学变异,我们比较了24名未接受过异性激素治疗的MTF变性欲者和24名年龄匹配的对照男性的大脑皮层区域厚度。结果显示,MTF变性人的左半球(即额叶和眶额叶皮质、中央沟、外围区、中央旁回)和右半球(即中央前/后回、顶叶皮质、颞叶皮质、楔前叶、梭状回、舌回和眶额回)的皮质更厚。结论:这些发现提供了进一步的证据,证明大脑解剖学与性别认同有关,在MTF中,变性人的测量似乎从性别一致的男性转移了。
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