High plasma fibrinogen concentration and platelet count unfavorably impact survival in non-small cell lung cancer patients with brain metastases.

Q Medicine 癌症 Pub Date : 2014-02-01 Epub Date: 2013-08-19 DOI:10.5732/cjc.012.10307
Jian-Fei Zhu, Ling Cai, Xue-Wen Zhang, Yin-Sheng Wen, Xiao-Dong Su, Tie-Hua Rong, Lan-Jun Zhang
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引用次数: 35

Abstract

High expression of fibrinogen and platelets are often observed in non-small cell lung cancer (NSCLC) patients with local regional or distant metastasis. However, the role of these factors remains unclear. The aims of this study were to evaluate the prognostic significance of plasma fibrinogen concentration and platelet count, as well as to determine the overall survival of NSCLC patients with brain metastases. A total of 275 NSCLC patients with brain metastasis were enrolled into this study. Univariate analysis showed that high plasma fibrinogen concentration was associated with age≥65 years (P = 0.011), smoking status (P = 0.009), intracranial symptoms (P = 0.022), clinical T category (P = 0.010), clinical N category (P = 0.003), increased partial thromboplastin time (P < 0.001), and platelet count (P < 0.001). Patients with low plasma fibrinogen concentration demonstrated longer overall survival compared with those with high plasma fibrinogen concentration (median, 17.3 months versus 11.1 months; P≤0.001). A similar result was observed for platelet counts (median, 16.3 months versus 11.4 months; P = 0.004). Multivariate analysis showed that both plasma fibrinogen concentration and platelet count were independent prognostic factors for NSCLC with brain metastases (R2 = 1.698, P < 0.001 and R2 = 1.699, P < 0.001, respectively). Our results suggest that high plasma fibrinogen concentration and platelet count indicate poor prognosis for NSCLC patients with brain metastases. Thus, these two biomarkers might be independent prognostic predictors for this subgroup of NSCLC patients.

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高血浆纤维蛋白原浓度和血小板计数对非小细胞肺癌脑转移患者的生存有不利影响。
纤维蛋白原和血小板高表达常见于局部、区域或远处转移的非小细胞肺癌(NSCLC)患者。然而,这些因素的作用仍不清楚。本研究的目的是评估血浆纤维蛋白原浓度和血小板计数的预后意义,以及确定NSCLC脑转移患者的总生存期。本研究共纳入275例脑转移的非小细胞肺癌患者。单因素分析显示,高血浆纤维蛋白原浓度与年龄≥65岁(P = 0.011)、吸烟(P = 0.009)、颅内症状(P = 0.022)、临床T型(P = 0.010)、临床N型(P = 0.003)、部分凝血活酶时间增加(P < 0.001)和血小板计数(P < 0.001)相关。血浆纤维蛋白原浓度低的患者比血浆纤维蛋白原浓度高的患者总生存期更长(中位数,17.3个月对11.1个月;P≤0.001)。在血小板计数方面也观察到类似的结果(中位数,16.3个月对11.4个月;P = 0.004)。多因素分析显示,血浆纤维蛋白原浓度和血小板计数是NSCLC合并脑转移的独立预后因素(R2 = 1.698, P < 0.001和R2 = 1.699, P < 0.001)。我们的研究结果表明,高血浆纤维蛋白原浓度和血小板计数表明NSCLC脑转移患者预后不良。因此,这两种生物标志物可能是该亚组非小细胞肺癌患者的独立预后预测因子。
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来源期刊
癌症
癌症 ONCOLOGY-
CiteScore
3.47
自引率
0.00%
发文量
9010
审稿时长
12 weeks
期刊介绍: In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.
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