Pub Date : 2018-12-01DOI: 10.3872/J.ISSN.1007-385X.2018.09.002
Shaoxian Wu, J. Xia, Jingting Jiang
{"title":"New strategies for CAR-T cell in the treatment of solid tumors","authors":"Shaoxian Wu, J. Xia, Jingting Jiang","doi":"10.3872/J.ISSN.1007-385X.2018.09.002","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2018.09.002","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"127 1","pages":"854-858"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75395379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-01DOI: 10.3872/J.ISSN.1007-385X.2018.08.004
Min Liu, Jian Wang, Qian Sun, Wenwen Yu, F. Wei, X. Ren
{"title":"Effect of myeloid-derived suppressor cells on B cell function in mice bearing breast cancer","authors":"Min Liu, Jian Wang, Qian Sun, Wenwen Yu, F. Wei, X. Ren","doi":"10.3872/J.ISSN.1007-385X.2018.08.004","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2018.08.004","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"17 1","pages":"772-777"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88916591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.3872/J.ISSN.1007-385X.2016.03.017
Yuling Li, Hua Zhao, F. Wei, Lili Yang, X. Ren
{"title":"Influence of VEGF-C/VEGFR3 signaling pathway on dendritic cells derived from peripheral blood of tumor patients","authors":"Yuling Li, Hua Zhao, F. Wei, Lili Yang, X. Ren","doi":"10.3872/J.ISSN.1007-385X.2016.03.017","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2016.03.017","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"22 1","pages":"392-396"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82661755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01DOI: 10.3872/J.ISSN.1007-385X.2016.03.013
Y. Sang, J. Mei, Wenwen Yu, Xiying Zhang, F. Wei, Jinpu Yu, X. Ren
{"title":"The relationship of microsatellite instability with infiltration of T lymphocytes in tissues of non-small cell lung cancer","authors":"Y. Sang, J. Mei, Wenwen Yu, Xiying Zhang, F. Wei, Jinpu Yu, X. Ren","doi":"10.3872/J.ISSN.1007-385X.2016.03.013","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2016.03.013","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"51 1","pages":"371-377"},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73379477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-04-01DOI: 10.3872/J.ISSN.1007-385X.2015.02.009
W. Feng, R. Xiu-bao
{"title":"New horizons in target antigen selection in adoptive cell therapy of cancer","authors":"W. Feng, R. Xiu-bao","doi":"10.3872/J.ISSN.1007-385X.2015.02.009","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2015.02.009","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"8 3 1","pages":"191-196"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80969117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3872/J.ISSN.1007-385X.2015.02.018
Ma Xiaofei, Qian Yaqin, Z. Hua, Yu Jinpu, W. Feng, Anthony T Yang, Yu Wenwen, L. Hui, R. Xiu-bao
{"title":"Changes in and prognostic value of peripheral blood CD8+ T cells in melanoma patients before and after GVAX treatment","authors":"Ma Xiaofei, Qian Yaqin, Z. Hua, Yu Jinpu, W. Feng, Anthony T Yang, Yu Wenwen, L. Hui, R. Xiu-bao","doi":"10.3872/J.ISSN.1007-385X.2015.02.018","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2015.02.018","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"55 1","pages":"240-245"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75793607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-01-01DOI: 10.3872/J.ISSN.1007-385X.2015.1.021
Lili Yang, Yaqin Qian, X. Ren
{"title":"Telomeres and telomerase in T cells of tumor immunity","authors":"Lili Yang, Yaqin Qian, X. Ren","doi":"10.3872/J.ISSN.1007-385X.2015.1.021","DOIUrl":"https://doi.org/10.3872/J.ISSN.1007-385X.2015.1.021","url":null,"abstract":"","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"19 1","pages":"51-54"},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86039973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-12-01Epub Date: 2014-10-17DOI: 10.5732/cjc.014.10191
Lili Li, Yuan Zhang, Bing-Bing Guo, Francis K L Chan, Qian Tao
Epstein-Barr virus (EBV) is a well-known human herpesvirus associated with virtually all nasopharyngeal carcinoma (NPC) and approximately 10% of gastric cancer (GC) worldwide. Increasing evidence shows that acquired genetic and epigenetic alterations lead to the initiation and progression of NPC and GC. However, even deep whole exome sequencing studies showed a relatively low frequency of gene mutations in NPC and EBV-associated GC (EBVaGC), suggesting a predominant role of epigenetic abnormities, especially promoter CpG methylation, in the pathogenesis of NPC and EBVaGC. High frequencies of promoter methylation of tumor suppressor genes (TSGs) have been frequently reported in NPC and EBVaGC, with several EBV-induced methylated TSGs identified. Further characterization of the epigenomes (genome-wide CpG methylation profile--methylome) of NPC and EBVaGC shows that these EBV-associated tumors display a unique high CpG methylation epigenotype with more extensive gene methylation accumulation, indicating that EBV acts as a direct epigenetic driver for these cancers. Mechanistically, oncogenic modulation of cellular CpG methylation machinery, such as DNA methyltransferases (DNMTs), by EBV-encoded viral proteins accounts for the EBV-induced high CpG methylation epigenotype in NPC and EBVaGC. Thus, uncovering the EBV-associated unique epigenotype of NPC and EBVaGC would provide new insight into the molecular pathogenesis of these unique EBV-associated tumors and further help to develop pharmacologic strategies targeting cellular methylation machinery in these malignancies.
{"title":"Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells.","authors":"Lili Li, Yuan Zhang, Bing-Bing Guo, Francis K L Chan, Qian Tao","doi":"10.5732/cjc.014.10191","DOIUrl":"https://doi.org/10.5732/cjc.014.10191","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) is a well-known human herpesvirus associated with virtually all nasopharyngeal carcinoma (NPC) and approximately 10% of gastric cancer (GC) worldwide. Increasing evidence shows that acquired genetic and epigenetic alterations lead to the initiation and progression of NPC and GC. However, even deep whole exome sequencing studies showed a relatively low frequency of gene mutations in NPC and EBV-associated GC (EBVaGC), suggesting a predominant role of epigenetic abnormities, especially promoter CpG methylation, in the pathogenesis of NPC and EBVaGC. High frequencies of promoter methylation of tumor suppressor genes (TSGs) have been frequently reported in NPC and EBVaGC, with several EBV-induced methylated TSGs identified. Further characterization of the epigenomes (genome-wide CpG methylation profile--methylome) of NPC and EBVaGC shows that these EBV-associated tumors display a unique high CpG methylation epigenotype with more extensive gene methylation accumulation, indicating that EBV acts as a direct epigenetic driver for these cancers. Mechanistically, oncogenic modulation of cellular CpG methylation machinery, such as DNA methyltransferases (DNMTs), by EBV-encoded viral proteins accounts for the EBV-induced high CpG methylation epigenotype in NPC and EBVaGC. Thus, uncovering the EBV-associated unique epigenotype of NPC and EBVaGC would provide new insight into the molecular pathogenesis of these unique EBV-associated tumors and further help to develop pharmacologic strategies targeting cellular methylation machinery in these malignancies.</p>","PeriodicalId":10034,"journal":{"name":"Chinese Journal of Cancer","volume":"33 12","pages":"604-8"},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5732/cjc.014.10191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32753781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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