Standards of care and novel approaches in the management of glioblastoma multiforme.

Q Medicine 癌症 Pub Date : 2014-01-01 DOI:10.5732/cjc.013.10207
Andreas F Hottinger, Roger Stupp, Krisztian Homicsko
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引用次数: 120

Abstract

Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults. Standard therapeutic approaches provide modest improvement in the progression-free and overall survival, necessitating the investigation of novel therapies. We review the standard treatment options for GBM and evaluate the results obtained in clinical trials for promising novel approaches, including the inhibition of angiogenesis, targeted approaches against molecular pathways, immunotherapies, and local treatment with low voltage electric fields.

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多形性胶质母细胞瘤的治疗标准和新方法。
多形性胶质母细胞瘤(GBM)是成人最常见的原发性恶性脑肿瘤。标准治疗方法在无进展和总生存率方面提供了适度的改善,因此需要研究新的治疗方法。我们回顾了GBM的标准治疗方案,并评估了在临床试验中获得的有前景的新方法的结果,包括抑制血管生成、靶向分子途径、免疫疗法和低压电场局部治疗。
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来源期刊
癌症
癌症 ONCOLOGY-
CiteScore
3.47
自引率
0.00%
发文量
9010
审稿时长
12 weeks
期刊介绍: In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.
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