[Synthesis of aminopropylaminoderivatives of betulinic and oleanolic acids].

G V Giniiatullina, O B Kazakova, N I Medvedeva, I V Sorokina, N A Zhukova, T G Tolstikova, G A Tolstikov
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Abstract

On the basis of betulinic and oleanolic acids triterpenoids with different with different amine fragments: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, (3-aminopropyl)-4-aminosulfonyl-4-phenylamino- at positions C3 and C28 were synthesized. It is shown that betulonic acid amide with 4,4'-diaminodiphenylsulfonic substituent don't render antitumor effect in mice with transplantable Lewis lung carcinoma, but possess significant anti-inflammatory activity.

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[白桦酸和齐墩果酸的氨基丙基氨基衍生物的合成]。
在白桦脂酸和齐墩果酸的基础上,合成了3-氨基丙氧基-、3-乙酰基-(3-氨基丙基)氨基-、6-[双(3-氨基丙基)氨基]己基氨基-、(3-氨基丙基)-4-氨基磺酰基-4-苯基氨基-等具有不同胺片段的三萜化合物。结果表明,含4,4′-二氨基二苯磺酸取代基的苯二酸酰胺对可移植Lewis肺癌小鼠无抗肿瘤作用,但具有明显的抗炎活性。
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