Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats

Regulatory Peptides Pub Date : 2014-02-10 DOI:10.1016/j.regpep.2013.12.009

Peter Spégel , Andreas Lindqvist , Monica Sandberg , Nils Wierup

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引用次数: 1

Abstract

Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (− 26%, p < 0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats. Interestingly, levels of branched chain amino acids and the ketone body β-hydroxybutyrate were decreased by 21% (p < 0.05) and 27% (p < 0.001), respectively, in hyperglycemic rats infused with 60 ng/ml GIP. Hence, our data suggest that GIP provokes a decrease in BCAA levels and ketone body production. Increased concentrations of these metabolites have been associated with obesity and T2D.

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葡萄糖依赖型胰岛素多肽降低高血糖大鼠支链氨基酸

胰促胰岛素激素葡萄糖依赖性胰岛素多肽(GIP)的高分泌与肥胖和葡萄糖耐受不良有关。这种情况已被认为与GIP抗性有关。除促胰岛素作用外，GIP还直接影响葡萄糖摄取和脂质代谢。尽管如此，除葡萄糖外，GIP对其他循环代谢物的影响尚未得到彻底研究。在这里，我们研究了在正常和高血糖大鼠中输注不同浓度的GIP对血清代谢物谱的影响。我们发现，尽管血清葡萄糖水平下降(- 26%，p <0.01)，正常血糖大鼠血清代谢物谱基本不受GIP输注的影响。有趣的是，支链氨基酸和酮体β-羟基丁酸水平降低了21% (p <0.05)和27% (p <0.001)，分别在注射60 ng/ml GIP的高血糖大鼠中。因此，我们的数据表明，GIP引起BCAA水平和酮体生成的降低。这些代谢物浓度的增加与肥胖和糖尿病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Regulatory Peptides 医学-内分泌学与代谢

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2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.