Does acupuncture therapy improve language function of patients with aphasia following ischemic stroke? A systematic review and meta-analysis.

Regulatory Peptides Pub Date : 2022-01-01 DOI:10.3233/NRE-220007

Bomo Sang, Shizhe Deng, Jingbo Zhai, Ting Hao, Bifang Zhuo, Chenyang Qin, Menglong Zhang, Xiaofeng Zhao, Zhihong Meng

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Abstract

Background: Aphasia is one of the most common complications in patients with ischemic stroke. Studies have shown that acupuncture can improve the symptoms of aphasia patients. However, the effect of acupuncture on language function in patients with ischemic stroke is still controversial.

Objective: This study aimed to critically assess the efficacy and safety of acupuncture for aphasia following ischemic stroke.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science Core Collection, China National Knowledge Infrastructure, Wanfang Digital Periodicals, and Chinese Science and Technology Periodicals database were searched. All randomized controlled trials (RCTs) that met the criteria were included.

Results: Meta-analyses showed that mean difference in change of auditory comprehension score (MD = 7.71, 95% CI: 1.83 to 13.59, P = 0.01), spontaneous speech (MD = 2.77, 95% CI: 0.59 to 4.95, P = 0.01), repetition score (MD = 14.48, 95% CI: 11.04 to 17.91, P < 0.00001) and naming score (MD = 14.60, 95% CI: 11.33 to 17.88, P < 0.00001) measured by WAB scale were statistically significant. Subgroup analyses demonstrated that there were statistically significant mean differences in four items of WAB scale in patients with sub-acute stroke, and no statistically significant differences in patients with acute stroke.

Conclusion: The present study suggests that acupuncture may improve the language function of patients with aphasia following ischemic stroke, especially during the sub-acute phase. However, due to insufficient sample sizes and information on the safety, more high-quality RCTs are still needed.

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针灸疗法能改善缺血性中风失语患者的语言功能吗？系统回顾与荟萃分析。

背景：失语症是缺血性脑卒中患者最常见的并发症之一：失语症是缺血性中风患者最常见的并发症之一。研究表明，针灸可以改善失语症患者的症状。然而，针灸对缺血性中风患者语言功能的影响仍存在争议：本研究旨在严格评估针灸治疗缺血性中风失语症的有效性和安全性：方法：检索了 PubMed、Embase、Cochrane Central Register of Controlled Trials、Web of Science Core Collection、China National Knowledge Infrastructure、万方数据期刊网和中国科技期刊数据库。所有符合标准的随机对照试验（RCT）均被纳入：Meta分析表明，听觉理解力评分（MD=7.71，95% CI：1.83～13.59，P=0.01）、自发言语（MD=2.77，95% CI：0.59～4.95，P=0.01）、复述评分（MD=14.48，95% CI：11.04～17.91，P 结论：本研究表明，针灸可改善听觉理解力评分、自发言语、复述评分、听力理解力评分和听力理解力评分的变化：本研究表明，针灸可改善缺血性脑卒中失语患者的语言功能，尤其是在亚急性期。然而，由于样本量和安全性方面的信息不足，仍需要更多高质量的 RCT 研究。

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Regulatory Peptides 医学-内分泌学与代谢

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2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.