Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases.

Indian Journal of Virology Pub Date : 2013-12-01 Epub Date: 2013-09-06 DOI:10.1007/s13337-013-0162-z
Vinay Ganeshrao Joshi, Vikas D Dighe, Dimpal Thakuria, Yashpal Singh Malik, Satish Kumar
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引用次数: 48

Abstract

The peptide dendrimer provides novel strategies for various biological applications. Assembling of peptide in macromolecular structure is expected to give rational models as drugs, their delivery and diagnostic reagents. Improved understanding of virus structure and their molecular interactions with ligands have paved the way for treatment and control of emerging and re-emerging viral diseases. This review presents a brief account of a synthetic peptide dendrimer used for diagnostic, therapeutic and prophylactic applications. The designs comprise of multiple antigenic peptides which are being used as alternate synthetic antigens for different viruses.

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多抗原肽(MAP):一种用于新出现和再出现的病毒性疾病的诊断、抗病毒和疫苗策略的合成肽树状聚合物。
肽树状大分子为各种生物学应用提供了新的策略。多肽在大分子结构上的组装有望为药物、给药和诊断试剂提供合理的模型。对病毒结构及其与配体的分子相互作用的进一步了解为治疗和控制新出现和再出现的病毒性疾病铺平了道路。本文综述了一种用于诊断、治疗和预防应用的合成肽树状大分子的简要介绍。该设计包括多个抗原肽,这些抗原肽被用作不同病毒的替代合成抗原。
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来源期刊
Indian Journal of Virology
Indian Journal of Virology 医学-病毒学
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6-12 weeks
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Role of genomic and proteomic tools in the study of host-virus interactions and virus evolution. Multiple antigenic peptide (MAP): a synthetic peptide dendrimer for diagnostic, antiviral and vaccine strategies for emerging and re-emerging viral diseases. Sheep associated malignant catarrhal fever: an emerging disease of bovids in India. Isolation and characterization of low pathogenic H9N2 avian influenza A viruses from a healthy flock and its comparison to other H9N2 isolates. Bovine immunodeficiency virus: a lentiviral infection.
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