Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease

IF 4.7 4区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nanomedicine: Nanotechnology, Biology and Medicine Pub Date : 2023-07-01 DOI:10.1016/j.nano.2023.102689

Bruno Fonseca-Santos PhD , Camila André Cazarin MSc , Patrícia Bento da Silva PhD , Kaio Pini dos Santos PhD , Márcia Cristina Oliveira da Rocha PhD , Sônia Nair Báo PhD , Márcia Maria De-Souza PhD , Marlus Chorilli PhD

{"title":"Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease","authors":"Bruno Fonseca-Santos PhD , Camila André Cazarin MSc , Patrícia Bento da Silva PhD , Kaio Pini dos Santos PhD , Márcia Cristina Oliveira da Rocha PhD , Sônia Nair Báo PhD , Márcia Maria De-Souza PhD , Marlus Chorilli PhD","doi":"10.1016/j.nano.2023.102689","DOIUrl":null,"url":null,"abstract":"<div>Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.</div>","PeriodicalId":396,"journal":{"name":"Nanomedicine: Nanotechnology, Biology and Medicine","volume":"51 ","pages":"Article 102689"},"PeriodicalIF":4.7000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine: Nanotechnology, Biology and Medicine","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1549963423000400","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 2

Abstract

Alzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

鼻内原位胶凝液晶传递白藜芦醇改善阿尔茨海默病的记忆和神经炎症

阿尔茨海默病(AD)是一种影响65岁或以上人群的疾病，在美国约有650万人受到影响。白藜芦醇是一种从天然产物中获得的化学物质，它具有抑制淀粉样蛋白形成、解聚和减少神经炎症的生物活性。由于该化合物的不溶性;其结合在表面活性剂为基础的系统被提议设计一种鼻内制剂。通过将油酸、CETETH-20和水混合，可以生产出一系列的体系。偏振光显微镜(PLM)、小角度x射线散射(SAXS)和透射电子显微镜(TEM)证实了初始液体配方(F)为微乳液(ME)。稀释后的凝胶体系为六边形中间相，具有可行性。经鼻给药后进行的药理学分析显示，该药物能够改善动物的学习和记忆能力，并通过抑制白细胞介素缓解神经炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nanomedicine: Nanotechnology, Biology and Medicine 医学-纳米科技

CiteScore

8.10

自引率

3.60%

发文量

104

审稿时长

4.6 months

期刊介绍： Nanomedicine: Nanotechnology, Biology and Medicine (NBM) is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.