Effect of Aqueous Extract of Giant Horsetail (Equisetum giganteum L.) in Antigen-Induced Arthritis.

Q4 Medicine Open Rheumatology Journal Pub Date : 2013-12-30 eCollection Date: 2013-01-01 DOI:10.2174/1874312901307010129

Mirian Farinon, Priscila Schmidt Lora, Leandro Nicolodi Francescato, Valquiria Linck Bassani, Amélia Teresinha Henriques, Ricardo Machado Xavier, Patricia Gnieslaw de Oliveira

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引用次数: 15

Abstract

Equisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P < 0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory effect on both B and T lymphocytes, with an action independent of cytotoxicity.

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巨马尾水提物对抗原性关节炎的作用。

木贼草是传统医学中用作利尿剂的植物。据我们所知，这是这种植物第一次在急性炎症的体内模型中进行测试。为了评价巨马尾水提物(AEGH)作为免疫调节疗法的作用，用甲基化牛血清白蛋白(mBSA)诱导小鼠产生抗原诱导关节炎(AIA)。通过关节痛觉、白细胞迁移和淋巴细胞增殖来评估炎症反应。AEGH在第3、6和24 h降低了痛觉(P < 0.01)，降低了白细胞迁移(P < 0.015)，抑制了刀豆蛋白A和脂多糖刺激的淋巴细胞增殖(P < 0.05)。综上所述，AEGH在急性炎症模型中具有抗炎潜能，同时对B淋巴细胞和T淋巴细胞具有免疫调节作用，且作用独立于细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Rheumatology Journal Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

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期刊介绍： ENTHAM Open publishes a number of peer-reviewed, open access journals. These free-to-view online journals cover all major disciplines of science, medicine, technology and social sciences. BENTHAM Open provides researchers a platform to rapidly publish their research in a good-quality peer-reviewed journal. All peer-reviewed accepted submissions meeting high research and ethical standards are published with free access to all.