Open Rheumatology Journal最新文献

Clinical Features, Socio-cultural Characteristics, Sleep Patterns, and Depression in Fibromyalgia Patients from India: A Cross-Sectional Study 印度纤维肌痛患者的临床特征、社会文化特征、睡眠模式和抑郁:一项横断面研究

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-10-25 DOI: 10.2174/0118743129267713231006113813

Smruti Ramteke, Sanjay Ramteke, Sandeep Yadav, Nitin Chandak

Fibromyalgia (FM) is a complex and chronic disease with significant regional variation. There is a lack of studies on Fibromyalgia (FM) in Indian population. The aim of this study is to investigate the clinical features of FM patients in India, including the prevalence and distribution of comorbidities, sleep patterns, and depression. Cross-sectional analysis of patients attending outpatient rheumatology clinic from 2019-2020 fell in the ACR2016 criteria for FM. Of the 121 patients enrolled in the study, the majority (93.4%) were female, with a female-to-male ratio of 14:1. The mean age of the patients was 45 ±11 years. The socio-cultural profile of the patients revealed that the majority were married (88%) and homemakers (68.8%), lived in nuclear families (56%) and were middle to upper middle class (68.6%). Contrary to the existing literature, a higher prevalence of FM has been observed in people with a higher educational status. Common clinical symptoms were extensive body aches (100%), fatigue (88%), difficulty concentrating (69.4%), irritability and gastrointestinal complaints (58.5%). We observed a high prevalence of primary headache (76%), mainly migraine (42%) and obsessive-compulsive (OCB) (71%). Sleep disturbances and depression were found in the significant number of patients with FM. The patients reported various sleep problems, such as snoring, waking up at night, daytime sleepiness, and taking daytime naps. Most of the patients had mild (50.8%) to moderate (29%) depression, while a smaller proportion experienced severe (6.6%) symptoms. Most of the patients had low serum vitamin D (91%). The presence of moderate to severe depression was associated with the severity of FM. The demographic profile of Indian patients was similar to that reported in the literature but had varied socio-cultural profiles needing further community-based studies. The high prevalence of psychological comorbidities and sleep disturbances highlights their importance in managing FM patients.

纤维肌痛(FM)是一种复杂的慢性疾病，具有显著的区域差异。印度人群中纤维肌痛(FM)的研究缺乏。目的:本研究旨在探讨印度FM患者的临床特征，包括合并症、睡眠模式和抑郁的患病率和分布。方法:对2019-2020年在风湿病门诊就诊的符合ACR2016 FM标准的患者进行横断面分析。结果:121例入组患者中，绝大多数(93.4%)为女性，男女比例为14:1。患者平均年龄45±11岁。患者的社会文化特征显示，大多数是已婚(88%)和家庭主妇(68.8%)，生活在核心家庭(56%)和中上层中产阶级(68.6%)。与现有文献相反，FM在受教育程度较高的人群中患病率更高。常见的临床症状为广泛的身体疼痛(100%)、疲劳(88%)、注意力难以集中(69.4%)、烦躁和胃肠道不适(58.5%)。我们观察到原发性头痛的患病率很高(76%)，主要是偏头痛(42%)和强迫症(71%)。大量FM患者存在睡眠障碍和抑郁。患者报告了各种睡眠问题，如打鼾、夜间醒来、白天嗜睡和白天小睡。大多数患者表现为轻度(50.8%)至中度(29%)抑郁，少部分患者表现为重度(6.6%)抑郁。大多数患者血清维生素D水平较低(91%)。中度至重度抑郁症的存在与FM的严重程度相关。结论:印度患者的人口统计特征与文献报道相似，但具有不同的社会文化特征，需要进一步的社区研究。心理合并症和睡眠障碍的高患病率突出了它们在管理FM患者中的重要性。

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引用次数: 0

The Diagnostic Significance of Serum Sclerostin in Early Detection of Rheumatoid Arthritis in Syrian Patients 血清硬化蛋白在叙利亚类风湿关节炎早期诊断中的意义

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-10-23 DOI: 10.2174/0118743129257178231005074615

Rama Hussein, Imad Aboukhamis

Background: Rheumatoid arthritis (RA) is associated with joint deformities and local bone erosions. Sclerostin is an inhibitor of the Wnt pathway and drives to reduce bone formation. Aims: Our study aimed to compare the diagnostic significance of sclerostin with anti-CCP (anti-cyclic citrullinated peptide; normal level<20 IU/ml, and rheumatoid factor (RF; normal level<16 IU/ml) for the early diagnosis of rheumatoid arthritis in Syrian patients. Methods: This study contained fifty-eight RA patients and thirty healthy individuals who were equally age- and sex-matched. Serum sclerostin and serum anti-CCP (IgG) levels were evaluated by using the enzyme-linked immunosorbent assay (ELISA). RA activity was assessed based on disease activity scores (DAS28). Results: Our results indicated that serum levels of sclerostin levels were higher in the RA group than in the healthy group (p<0.001). There was a positive correlation between serum sclerostin and DAS28-ESR (r=0.413, p=0.001). By ROC curve, the most optimal cut-off value of sclerostin was 249.69 pg/ml (AUC was 0.910 with 95% confidence interval (CI) values (0.852-0.969), sensitivity of 87.9%, and specificity of 93.3%) [Odds Ratio (OR) and P-value: 102, P< 0.0001]. In RA patients, the sensitivity and specificity of anti-CCP were 74.1% and 90%, and 70.6% and 86.6% of RF, respectively. Conclusion: Increased serum sclerostin may aid as a new prognostic biomarker for evaluating the activity of RA. Sclerostin showed higher sensitivity and specificity than anti-CCP and RF-IgM antibodies. Therefore, sclerostin is a sensitive and specific biomarker for early diagnosis of rheumatoid arthritis.

背景:类风湿性关节炎(RA)与关节畸形和局部骨侵蚀有关。硬化蛋白是Wnt通路的一种抑制剂，并驱动减少骨形成。目的:比较硬化蛋白(sclerostin)与抗环瓜氨酸肽(anti-CCP)的诊断意义;正常水平20 IU/ml，类风湿因子(RF;正常水平(16 IU/ml)用于叙利亚患者类风湿性关节炎的早期诊断。方法:本研究包括58名RA患者和30名年龄和性别相同的健康个体。采用酶联免疫吸附试验(ELISA)测定血清硬化蛋白(sclerostin)和血清抗ccp (IgG)水平。根据疾病活动度评分(DAS28)评估RA活动性。结果:我们的研究结果表明，RA组的血清硬化素水平高于健康组(p<0.001)。血清硬化蛋白与DAS28-ESR呈正相关(r=0.413, p=0.001)。ROC曲线显示，最优截断值为249.69 pg/ml (AUC为0.910,95%可信区间(CI)为0.852 ~ 0.969)，敏感性为87.9%，特异性为93.3%)[比值比(OR)和p值:102,P<0.0001]。RA患者抗ccp的敏感性和特异性分别为74.1%和90%，RF的敏感性和特异性分别为70.6%和86.6%。结论:血清硬化蛋白升高可作为评估RA活性的一种新的预后生物标志物。与抗ccp抗体和RF-IgM抗体相比，Sclerostin具有更高的敏感性和特异性。因此，硬化蛋白是类风湿关节炎早期诊断的敏感特异性生物标志物。

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引用次数: 0

Clinical Characteristics of Systemic Sclerosis-associated Myopathy Patients Comparing Different Subgroups of Inflammatory Myopathies 系统性硬化症相关肌病患者的临床特征:炎性肌病不同亚组的比较

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-10-04 DOI: 10.2174/18743129-v17-e230925-2023-4

Songkiet Suwansirikul, Jirapath Intum, Chontichaporn Tejamai, Suparaporn Wangkaew

Available data regarding clinical characteristics of systemic sclerosis-associated myopathy (SSc-M) patients comparing different subgroups of muscle pathology are limited. We aimed to compare clinical and laboratory findings among different subgroups of Thai patients with SSc-M. From January 2010 to December 2019, 27 patients with suspected SSc-M underwent a muscle biopsy. Twenty-three patients with available frozen muscle biopsy specimens for repeating immunohistochemical stained for reviewing were included. There were three subgroups of pathological findings, including immune-mediated necrotizing myopathy (IMNM), non-specific myopthy (NsM), and polymyositis (PM). No fibrosing myopathy was observed. Baseline clinical data and laboratory findings were compared within those three inflammatory myopathies. Of the 23 SSc-M, there were 14 females and 19 DcSSc with a mean age and disease duration of SSc of 53.6±7.7 years and 16.4±23.6 months, respectively. Their mean duration from weakness to muscle biopsy was 3.6±6.0 months. There were 14 (60.9%) patients with IMNM, 6 (26.1%) with NsM, and 3 (13.0%) with PM. At the biopsy date, IMNM had a greater prevalence of severe muscle weakness (42.6% vs. 0% vs. 0%) and arthritis (87.5% vs. 50% vs. 0%) than the NsM and PM groups. There was no significant difference among the three inflammatory patterns regarding baseline clinical characteristics, including age, gender, SSc subtype, disease duration, other organ involvements and median values of CK and ESR levels. In this study, we found that the pathological findings of Thai SSc-M were IMNM, NsM, and PM. No fibrosing myopathy was observed. SSc with IMNM tended to have more severe baseline muscle weakness and arthritis than the other inflammatory patterns.

背景:关于系统性硬化症相关肌病(SSc-M)患者临床特征比较不同肌肉病理亚组的现有数据有限。我们的目的是比较泰国SSc-M患者不同亚组的临床和实验室结果。方法:2010年1月至2019年12月，27例疑似SSc-M患者进行了肌肉活检。23例可获得的冷冻肌肉活检标本用于重复免疫组织化学染色以进行回顾。病理结果分为三个亚组，包括免疫介导的坏死性肌病(IMNM)、非特异性肌病(NsM)和多发性肌炎(PM)。未见纤维化肌病。对这三种炎症性肌病的基线临床资料和实验室结果进行比较。结果:23例SSc- m中，女性14例，DcSSc 19例，SSc平均年龄53.6±7.7岁，病程16.4±23.6个月。从虚弱到肌肉活检的平均时间为3.6±6.0个月。IMNM 14例(60.9%)，NsM 6例(26.1%)，PM 3例(13.0%)。在活检日期，IMNM有更大的严重肌肉无力的患病率(42.6%比。0% vs。0%)和关节炎(87.5% vs。50% vs。0%)高于NsM和PM组。三种炎症模式在基线临床特征方面无显著差异，包括年龄、性别、SSc亚型、病程、其他器官受累以及CK和ESR水平的中值。结论:在本研究中，我们发现泰国SSc-M的病理表现为IMNM、NsM和PM。未见纤维化肌病。伴有IMNM的SSc倾向于比其他炎症模式更严重的基线肌无力和关节炎。

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引用次数: 0

Association of Interleukin-6 and Tumor Necrosis Factor-alpha Gene Polymorphisms with Gnetic Susceptibility of Psoriatic Arthritis in Kuwaiti Arab Patients 白细胞介素-6和肿瘤坏死因子- α基因多态性与科威特阿拉伯患者银屑病关节炎遗传易感性的关系

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-09-11 DOI: 10.2174/18743129-v17-e230714-2023-2

Adel M. Al-Awadhi, Mohammad Z. Haider, Aminah M. Al-Awadi, Anita K. Kalarikkal, Jalaja Sukumaran, Eman AH Hasan, Youssef A. Bartella

Background: Psoriatic arthritis (PsA) is an inflammatory arthritic disease in which joint inflammation occurs with psoriasis. It results from a complex interplay between genetic, immunological and environmental factors. In PsA, the activation of T cells is considered as a crucial step in the disease process. The T-lymphocytes affect the proliferation of epidermal skin cells and result in abnormal differentiation. Altered cytokine networks have been shown to play a central role in the pathogenesis of PsA. Psoriasis is characterized by Th-1 type cytokine pattern in which there is a marked variation in the secretion of interleukin-6 (IL6), interleukin-13 (IL13) and Tumor necrosis factor-alpha (TNF-alpha). This study investigated the association of IL6 , IL13 and TNF - alpha gene polymorphisms with genetic susceptibility of PsA in Kuwaiti patients. Methods: The genotypes of IL6 gene (-174G/C; rs1800795), IL13 gene (R130Q; rs20541) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms were detected in 113 Kuwaiti PsA patients and were compared to that in 104 healthy controls. The PsA patients were diagnosed on the basis of the presence of inflammatory arthritis with psoriasis with no rheumatoid factor in the serum. The genotypes for IL6 , IL13 and TNF-alpha gene polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods and were confirmed by DNA sequencing. Results: The frequency of IL6 gene (-174G/C; rs1800795) and TNF-alpha gene (-308A/G’ rs1800629) polymorphisms manifested a statistically significant difference between Kuwaiti PsA patients and controls. However, the frequency of IL13 gene (R130Q; rs20541) polymorphism did not show a significant difference between Kuwaiti PsA patients and the controls. Conclusion: Our data show an association of two cytokine gene polymorphisms in IL6 gene (-174G/C; rs1800795) and TNF-alpha gene (-308A/G’ rs1800629) with PsA in Kuwaiti patients highlighting their significant contribution to genetic susceptibility of this chronic disease possibly along with other factors.

背景:银屑病关节炎(Psoriatic arthritis, PsA)是一种伴有银屑病的关节炎症的炎性关节炎疾病。它是遗传、免疫和环境因素复杂相互作用的结果。在PsA中，T细胞的激活被认为是疾病过程中的关键步骤。t淋巴细胞影响表皮皮肤细胞的增殖并导致异常分化。细胞因子网络的改变已被证明在PsA的发病机制中起核心作用。银屑病以Th-1型细胞因子模式为特征，其中白细胞介素-6 (IL6)、白细胞介素-13 (IL13)和肿瘤坏死因子- α (tnf - α)的分泌有明显变化。本研究探讨了科威特患者中il - 6、il - 13和TNF - α基因多态性与PsA遗传易感性的关系。方法:il - 6基因分型(-174G/C;rs1800795)， IL13基因(R130Q;在113名科威特PsA患者中检测到rs20541)和tnf - α基因(-308A/G ' rs1800629)多态性，并与104名健康对照进行比较。PsA患者在血清中无类风湿因子的基础上诊断为银屑病炎症性关节炎。采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法确定IL6、IL13和tnf - α基因多态性的基因型，并进行DNA测序。结果:il - 6基因频率为-174G/C;rs1800795)和tnf - α基因(-308A/G ' rs1800629)多态性在科威特PsA患者与对照组之间存在统计学差异。然而，IL13基因(R130Q;rs20541)多态性在科威特PsA患者和对照组之间没有显着差异。结论:我们的数据显示两种细胞因子基因多态性在il - 6基因(-174G/C;rs1800795)和tnf - α基因(-308A/G ' rs1800629)在科威特患者中与PsA相关，突出了它们可能与其他因素一起对这种慢性疾病的遗传易感性有重要贡献。

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引用次数: 0

The Etiopathogenesis and Genetic Factors in Idiopathic Inflammatory Myopathies: A Review Article 特发性炎性肌病的发病机制及遗传因素综述

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-04-05 DOI: 10.2174/18743129-v17-e230327-2022-11

Gustavo-Esteban Lugo-Zamudio, Rosa-Elda Barbosa-Cobos, Lucía-Verónica Maya-Piña, Dolores Delgado-Ochoa, María-Mercedes López-Mayorga, Ivonne Arenas-Silva, Diana-Sarai Arellano-Álvarez

Introduction: Idiopathic inflammatory myopathies (IIM) are a group of heterogeneous systemic autoimmune diseases characterized by muscle inflammation from unknown causes resulting in chronic weakness. Recent studies have shown the role of the cellular immune response affecting muscle fibers in polymyositis (PM), inclusion body myositis, and to a lesser extent, dermatomyositis (DM), wherein humoral immunity is more involved. The value of genetic factors of the class II major histocompatibility complex (MHC II) has also been highlighted. In studies of murine models, the presence of HLA-DR3 favors a higher risk of developing inflammatory muscle disease, including PM and juvenile DM. In recent years, few studies have provided timely information regarding this, thus the researchers initially proposed a review of existing literature to broaden the context regarding what was described and to visualize proposals that may enhance the understanding of this group of inflammatory pathologies. Methods: The design, implementation, analysis, and reporting of this study were followed according to the search with MeSH terms (Autoimmune myopathy, Inflammatory myopathies, Idiopathic inflammatory myopathies AND Major histocompatibility complex and genetics). We analyzed 12 articles for this review article. Conclusion: In the etiopathogenesis of IIM, both humoral and cellular immunity are observed, considering the presence of a trigger that causes the immune response. As for the immunogenetics, this review highlights what has been reported in Chinese and Mexican populations, where HLADRB1*09:01 is related to the presence of DM, and is observed as the first variant identified in various populations. This increases interest in this allele in the particular case to study DM and strengthens research that proposes the study of IIM independently for each nosological entity.

特发性炎症性肌病(IIM)是一组异质性系统性自身免疫性疾病，其特征是未知原因的肌肉炎症导致慢性无力。最近的研究表明，细胞免疫反应在多发性肌炎(PM)、包涵体肌炎以及较小程度的皮肌炎(DM)中影响肌纤维的作用，其中体液免疫更多地参与。II类主要组织相容性复合体(MHC II)的遗传因素的价值也被强调。在对小鼠模型的研究中，HLA-DR3的存在增加了发生炎性肌肉疾病的风险，包括PM和幼年型DM。近年来，很少有研究提供了关于这方面的及时信息，因此研究人员最初提出了对现有文献的回顾，以扩大所描述的背景，并提出可视化的建议，以增强对这组炎症病理的理解。方法:根据MeSH术语(自身免疫性肌病、炎症性肌病、特发性炎症性肌病和主要组织相容性复合体和遗传学)的搜索，跟踪本研究的设计、实施、分析和报告。我们为这篇综述文章分析了12篇文章。结论:在IIM的发病机制中，考虑到存在引起免疫反应的触发因素，可以观察到体液免疫和细胞免疫。在免疫遗传学方面，本综述强调了在中国和墨西哥人群中报道的HLADRB1*09:01与DM的存在有关，并且在不同人群中观察到HLADRB1*09:01是第一个发现的变异。这增加了对该等位基因在特殊情况下研究糖尿病的兴趣，并加强了对每个病种实体独立研究IIM的研究。

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引用次数: 0

KiOmedine® CM-Chitosan is Effective for Treating Advanced Symptomatic Knee Osteoarthritis up to Six Months Following a Single Intra-Articular Injection: A Post Hoc Analysis of Aproove Clinical Study kiommedine®cm -壳聚糖在单次关节内注射后6个月有效治疗晚期症状性膝骨性关节炎:一项经批准的临床研究事后分析

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2023-02-14 DOI: 10.2174/18743129-v16-e220206-2022-19

P.J. Emans, G. Skaliczki, D. Haverkamp, J. Bentin, M. Chausson, M. Schifflers, N. Portelange

Background: Symptomatic knee osteoarthritis (OA) is typically treated with hyaluronan-based intra-articular injections. Advanced knee OA patients are often unresponsive to hyaluronan. KiOmedine ® Carboxymethyl-Chitosan (CM-Chitosan), a novel fluid implant, was safe and effective for treating symptomatic knee OA. Objective: The objective of this study is to describe the efficacy of a single injection of KiOmedine ® CM-Chitosan in advanced knee OA. Methods: Patients with advanced knee OA enrolled in the APROOVE trial and treated with KiOmedine ® CM-Chitosan were identified: subgroup-1, BMI >30 kg/m 2 and/or Kellgren Lawrence (KL) grade III (n=39), and subgroup-2, BMI >30 kg/m 2 and KL-grade III (n=8). Within-group analyses were performed using the WOMAC scores and OMERACT-OARSI responder criteria at 3 and 6 months. Results: In both subgroups, significant improvements in all WOMAC scores were observed at 3 and 6 months (p<0.001 for all comparisons). A high responder rate was observed at 3 and 6 months in subgroup-1 (63.2% and 65.8%) and in subgroup-2 (57.1% and 62.5%). Conclusion: This post hoc analysis of the APROOVE trial showed that a single intra-articular injection with KiOmedine ® CM-Chitosan could be an effective therapeutic option for patients with advanced knee OA. Clinical trial registration number: Clinicaltrial.gov identifier: Net30679208.

背景:症状性膝骨关节炎(OA)通常采用基于透明质酸的关节内注射治疗。晚期膝关节OA患者通常对透明质酸无反应。KiOmedine®羧甲基壳聚糖(cm -壳聚糖)是一种新型液体植入物，安全有效地治疗症状性膝关节炎。目的:本研究的目的是描述单次注射kiommedine®cm -壳聚糖治疗晚期膝关节OA的疗效。方法:纳入aprove试验并接受KiOmedine®cm -壳聚糖治疗的晚期膝关节OA患者被确定为:亚组1,BMI >30 kg/ m2和/或Kellgren Lawrence (KL) III级(n=39)，亚组2,BMI >30 kg/ m2和KL- III级(n=8)。在3个月和6个月时使用WOMAC评分和OMERACT-OARSI应答标准进行组内分析。结果:在两个亚组中，在3个月和6个月时观察到所有WOMAC评分的显著改善(p<0.001)。亚组1(63.2%和65.8%)和亚组2(57.1%和62.5%)在3个月和6个月时的应答率较高。结论:aprove试验的事后分析表明，单次关节内注射KiOmedine®cm -壳聚糖可能是晚期膝关节OA患者的有效治疗选择。临床试验注册号:Clinicaltrial.gov标识符:Net30679208。

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引用次数: 1

Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved. STAT4 rs7574865多态性与类风湿关节炎的关系:尚未解决的争论

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2018-10-24 eCollection Date: 2018-01-01 DOI: 10.2174/1874312901812010172

Iman Tarakji, Wafa Habbal, Fawza Monem

Background: STAT4 rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.

Objective: We investigated the distribution of STAT4 rs7574865 polymorphism in a group of Syrian RA patients.

Methods: Eighty-one RA patients and forty healthy controls were enrolled and STAT4 rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis.

Results: Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in STAT4 rs7574865 allele/genotype frequencies were found between ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls (P>0.05).

Conclusion: STAT4 rs7574865 TT genotype showed a potential impact on ACPA positivity in Syrian RA patients. However, STAT4 rs7574865 effect on RA onset and severity is minor compared to other genetic factors such as HLA-DRB1 shared epitope alleles.

背景:STAT4 rs7574865多态性在欧洲和东亚人群中与类风湿关节炎(RA)易感性明显相关，而其他国家的研究报告则相反。目的:研究STAT4 rs7574865多态性在叙利亚RA患者中的分布。方法:选取81例RA患者和40例健康对照者，采用直接测序法对STAT4 rs7574865进行基因分型。根据抗瓜氨酸蛋白抗体(Anti-Citrullinated Protein Antibodies, ACPA)水平对RA患者进行分层分析。结果:次要T等位基因频率在acpa阳性RA患者、acpa阴性RA患者和健康对照中分别为30.4%、16.7%和23.8%。STAT4 rs7574865等位基因/基因型频率在acpa阳性RA患者、acpa阴性RA患者和健康对照组之间无显著差异(P>0.05)。结论:STAT4 rs7574865 TT基因型对叙利亚RA患者的ACPA阳性有潜在影响。然而，与HLA-DRB1共享表位等位基因等其他遗传因素相比，STAT4 rs7574865对RA发病和严重程度的影响较小。

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引用次数: 7

SLE and Serum Complement: Causative, Concomitant or Coincidental? SLE与血清补体:病因、伴随还是巧合?

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2018-09-18 eCollection Date: 2018-01-01 DOI: 10.2174/1874312901812010171

Vaneet Sandhu, Michele Quan

引用次数: 0

Losartan, but not Enalapril and Valsartan, Inhibits the Expression of IFN-γ, IL-6, IL-17F and IL-22 in PBMCs from Rheumatoid Arthritis Patients. 氯沙坦抑制类风湿关节炎患者外周血中IFN-γ、IL-6、IL-17F和IL-22的表达，而依那普利和缬沙坦则没有。

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2018-09-18 eCollection Date: 2018-01-01 DOI: 10.2174/1874312901812010160

Pablo R G Cardoso, Katherine A Matias, Andrea T Dantas, Claudia D L Marques, Michelly C Pereira, Angela L B P Duarte, Moacyr Jesus Barreto de Melo Rego, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta

Background: Rheumatoid Arthritis (RA) is a chronic and inflammatory disease that affects about 1% of the world's population. Almost 70% of RA patients have a cardiovascular disease such as Systemic Arterial Hypertension (SAH). Inflammatory cytokines are clearly involved in the pathogenesis of RA and correlated with SAH.

Objective: It is necessary to understand whether the antihypertensive drugs have a dual effect as immunomodulators and which one is the best choice for RA SAH patients.

Methods: Peripheral Blood Mononuclear Cells (PBMCs) from 16 RA patients were purified and stimulated or not stimulated with anti-CD3 and anti-CD28 mAB and were treated with Enalapril, Losartan and Valsartan at 100μM. Patients were evaluated for clinical and laboratory variables including measures of disease activity by Clinical Disease Activity Index (CDAI) and Disease Activity Score (DAS28). Cytokines were quantified by ELISA sandwich.

Results: Losartan was able to reduce levels of IFN-γ (p = 0.0181), IL-6 (p = 0.0056), IL-17F (0.0046) and IL-22 (p = 0.0234) in RA patients. In addition, patients in remission and mild score (DAS28<3.2 and CDAI<10) had a better response to treatment. On the other hand, patients in moderate and severe activity had poor response to Losartan in cytokine inhibition.

Conclusion: PBMCs from RA patients are responsive in inhibiting proinflammatory cytokines using Losartan better than Enalapril and Valsartan and it could be a better antihypertensive choice for patients with RA and systemic arterial hypertension treatment.

背景:类风湿关节炎(RA)是一种慢性炎症性疾病，影响着世界上约1%的人口。几乎70%的类风湿性关节炎患者有心血管疾病，如全身性动脉高血压(SAH)。炎性细胞因子明显参与RA的发病过程，并与SAH相关。目的:有必要了解抗高血压药物是否具有免疫调节剂的双重作用，以及哪种药物是RA SAH患者的最佳选择。方法:对16例RA患者外周血单个核细胞进行纯化，分别用抗cd3和抗cd28单抗刺激或不刺激，分别用依那普利、氯沙坦和缬沙坦在100μM下处理。通过临床疾病活动性指数(CDAI)和疾病活动性评分(DAS28)评估患者的临床和实验室变量，包括疾病活动性的测量。ELISA夹心法测定细胞因子。结果:氯沙坦能够降低RA患者的IFN-γ (p = 0.0181)、IL-6 (p = 0.0056)、IL-17F(0.0046)和IL-22 (p = 0.0234)水平。结论:氯沙坦对RA患者PBMCs抑制促炎细胞因子的反应优于依那普利和缬沙坦，可作为RA合并全身性动脉高血压患者更好的降压选择。

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引用次数: 12

Plasma Saturated and Monounsaturated Fatty Acids in Behçet's Disease. 血浆饱和脂肪酸和单不饱和脂肪酸在behaperet病中的作用。

Q4 Medicine

Open Rheumatology Journal

Pub Date : 2018-08-31 eCollection Date: 2018-01-01 DOI: 10.2174/1874312901812010139

Meriam Messedi, Manel Naifar, Sahar Grayaa, Faten Frikha, Mariem Messoued, Mohamed Marouene Sethom, Moncef Feki, Naziha Kaabach, Zouheir Bahloul, Kamel Jamoussi, Fatma Ayedi

Background: Fatty Acid (FA) composition of serum has been associated with many markers of inflammation. In this study, we tried to examine plasma Saturated Fatty Acid (SFA) and Monounsaturated Fatty Acid (MUFA) composition in Behçet's Disease (BD) patients. The associations between the circulating FA levels and some markers of inflammation have also been investigated.

Methods: This study is a cross-sectional one. In fact, a total of 101 BD patients and healthy controls group of 99 subjects are enrolled. Gas Chromatograph equipped with a Capillary Split/Splitless Injector and flame ionization detector was used to analyze the plasma SFA and MUFA compositions. The high sensitivity C-Reactive Protein (hsCRP) and fibrinogen levels were measured using standard techniques.

Results: BD patients had significantly higher proportions of Mystiric Acid (MA), Palmitic Acid (PAM), Palmitoleic Acid (POA) and Stearoyl-CoA Desaturase (SCD)-16, compared to controls.The results revealed that patients with severe involvements had high levels of POA and total MUFA associated with higher SCD-16 activity compared to those with minor ones. The receiver operator characteristic curve analysis revealed that POA could well discriminate BD patients with severe clinical manifestations. In the bivariate analysis, hsCRP was found to be positively correlated with total SAFA and POA elongase activity index but negatively correlated with SCD-18 activity index. The STA, POA, elongase and SCD-16 activity index are correlated with fibrinogen. On the other hand, the multivariate analysis showed that POA remained associated with higher levels of hsCRP.

Conclusion: Unfavourable plasma SFA and MUFA profile were reported in BD patients. POA, which is associated with higher plasma hsCRP level, may play a role in the pathogenesis of BD.

背景:血清脂肪酸(FA)组成与许多炎症标志物有关。在这项研究中，我们试图检测behet病(BD)患者血浆饱和脂肪酸(SFA)和单不饱和脂肪酸(MUFA)组成。循环FA水平和一些炎症标志物之间的关系也被研究过。方法:本研究为横断面研究。事实上，共有101名BD患者和99名健康对照组被纳入研究。采用气相色谱仪，配备毛细管分裂/无分裂进样器和火焰电离检测器，分析了血浆中SFA和MUFA的成分。采用标准技术测定高灵敏度c反应蛋白(hsCRP)和纤维蛋白原水平。结果:BD患者的神秘酸(MA)、棕榈酸(PAM)、棕榈油酸(POA)和硬脂酰辅酶a去饱和酶(SCD)-16的比例明显高于对照组。结果显示，与轻微受累的患者相比，严重受累的患者具有高水平的POA和总MUFA，与较高的SCD-16活性相关。接受者操作者特征曲线分析显示，POA可以很好地区分临床表现严重的BD患者。双变量分析发现，hsCRP与总SAFA和POA延长酶活性指数呈正相关，与SCD-18活性指数呈负相关。STA、POA、伸长酶和SCD-16活性指数与纤维蛋白原相关。另一方面，多变量分析显示POA仍然与较高水平的hsCRP相关。结论:据报道，BD患者的血浆SFA和MUFA状况不佳。POA与较高的血浆hsCRP水平相关，可能在BD的发病机制中发挥作用。

{"title":"Plasma Saturated and Monounsaturated Fatty Acids in Behçet's Disease.","authors":"Meriam Messedi, Manel Naifar, Sahar Grayaa, Faten Frikha, Mariem Messoued, Mohamed Marouene Sethom, Moncef Feki, Naziha Kaabach, Zouheir Bahloul, Kamel Jamoussi, Fatma Ayedi","doi":"10.2174/1874312901812010139","DOIUrl":"https://doi.org/10.2174/1874312901812010139","url":null,"abstract":"Background: Fatty Acid (FA) composition of serum has been associated with many markers of inflammation. In this study, we tried to examine plasma Saturated Fatty Acid (SFA) and Monounsaturated Fatty Acid (MUFA) composition in Behçet's Disease (BD) patients. The associations between the circulating FA levels and some markers of inflammation have also been investigated.Methods: This study is a cross-sectional one. In fact, a total of 101 BD patients and healthy controls group of 99 subjects are enrolled. Gas Chromatograph equipped with a Capillary Split/Splitless Injector and flame ionization detector was used to analyze the plasma SFA and MUFA compositions. The high sensitivity C-Reactive Protein (hsCRP) and fibrinogen levels were measured using standard techniques.Results: BD patients had significantly higher proportions of Mystiric Acid (MA), Palmitic Acid (PAM), Palmitoleic Acid (POA) and Stearoyl-CoA Desaturase (SCD)-16, compared to controls.The results revealed that patients with severe involvements had high levels of POA and total MUFA associated with higher SCD-16 activity compared to those with minor ones. The receiver operator characteristic curve analysis revealed that POA could well discriminate BD patients with severe clinical manifestations. In the bivariate analysis, hsCRP was found to be positively correlated with total SAFA and POA elongase activity index but negatively correlated with SCD-18 activity index. The STA, POA, elongase and SCD-16 activity index are correlated with fibrinogen. On the other hand, the multivariate analysis showed that POA remained associated with higher levels of hsCRP.Conclusion: Unfavourable plasma SFA and MUFA profile were reported in BD patients. POA, which is associated with higher plasma hsCRP level, may play a role in the pathogenesis of BD.","PeriodicalId":39124,"journal":{"name":"Open Rheumatology Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36523663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3