Universality splitting in distribution of number of miRNA co-targets.

Systems and Synthetic Biology Pub Date : 2014-03-01 Epub Date: 2014-02-18 DOI:10.1007/s11693-014-9131-0
Mahashweta Basu, Nitai P Bhattacharyya, P K Mohanty
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Abstract

In a recent work (Basu et al., in EPL 105:28007, 2014) it was pointed out that the link-weight distribution of microRNA co-target network of a wide class of species are universal up to scaling. The number cell types, widely accepted as a measure of complexity, turns out to be proportional to these scale-factor. In this article we discuss additional universal features of these networks and show that, this universality splits if one considers distribution of number of common targets of three or more number of microRNAs. These distributions for different species can be collapsed onto two distinct set of universal functions, revealing the fact that the species which appeared in early evolution have different complexity measure compared to those appeared late.

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miRNA共靶点数量分布的普遍性分裂。
在最近的一项工作中(Basu et al., In EPL 105:28007, 2014)指出,广泛种类的microRNA共靶点网络的链接权重分布是普遍的,直至缩放。被广泛接受作为复杂性衡量标准的数字细胞类型,结果与这些比例因子成正比。在本文中,我们讨论了这些网络的其他普遍特征,并表明,如果考虑到三个或更多microrna的共同目标数量的分布,这种普遍性就会分裂。这些不同物种的分布可以归结为两组不同的通用函数,揭示了出现在进化早期的物种与出现在进化后期的物种具有不同的复杂性度量。
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