[A coexistence of the Dupuytren's disease and malignant neoplasms: a review].

Abstract

Dupuytren's disease is classified as a benign superficial fibromatosis, in which excessive proliferation of myofibroblats and formation of nodules and chords occurs, followed by development of finger contractures. The similarities between Dupuytren's disease and neoplasms were shown at molecular and clinical grounds. The objective of the study was to review of the literature investigating possible relationship between occurrence of Dupuytren's disease and malignancies. Review of the few available papers shows (1) statistically significantly increased malignant neoplasm mortality among men with advanced Dupuytren's disease, comparing to reference population and men with early stage of the disease, (2) statistically significantly increased malignant neoplasm morbidity, mainly related to smoking and alcohol consumption among patients (men and women) operated on for Dupuytren's disease and (3) increased sarcoma of the bone and soft tissue morbidity in patients 5 years after operation for Dupuytren's disease. Some genetical studies show also altered expression of the dehydrogenases ALDH2 and DHDH genes in patients with Dupuytren's disease and with digestive tract malignancies related to alcohol abuse.